Features of the course of diabetes mellitus in IgG4-associated disease
IgG4-related disease (IgG4-RD) is characterized by the appearance of tumor-like foci in one or more organs, occurring synchronously or metachronously, due to fibro-inflammatory changes with hypersecretion of immunoglobulin G subclass 4 (IgG4) in tissues and/or blood serum. Diabetes mellitus (DM) dev...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2023-08-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/13054 |
| _version_ | 1797255077953536000 |
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| author | T. S. Panevin A. V. Torgashina A. A. Movsesyan |
| author_facet | T. S. Panevin A. V. Torgashina A. A. Movsesyan |
| author_sort | T. S. Panevin |
| collection | DOAJ |
| description | IgG4-related disease (IgG4-RD) is characterized by the appearance of tumor-like foci in one or more organs, occurring synchronously or metachronously, due to fibro-inflammatory changes with hypersecretion of immunoglobulin G subclass 4 (IgG4) in tissues and/or blood serum. Diabetes mellitus (DM) develops among 43-68% of patients with IgG4-related pancreatitis. Diabetes against the background of IgG4-RD can be caused both by damage to the endocrine part of the pancreas and the use of glucocorticosteroids, but its course is moderate, with a rare need for insulin therapy. In both cases, the use of genetically engineered biological therapy with rituximab may be accompanied by an improvement in carbohydrate metabolism. This article describes the course of diabetes and the need for hypoglycemic therapy for 1.5 years in a patient treated with IgG4-RD. |
| first_indexed | 2024-03-08T15:19:20Z |
| format | Article |
| id | doaj.art-88d9d63197c44c818f60a59c02216a2f |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:00:07Z |
| publishDate | 2023-08-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-88d9d63197c44c818f60a59c02216a2f2024-03-20T11:48:05ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782023-08-0126437037410.14341/DM1305411038Features of the course of diabetes mellitus in IgG4-associated diseaseT. S. Panevin0A. V. Torgashina1A. A. Movsesyan2V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyIgG4-related disease (IgG4-RD) is characterized by the appearance of tumor-like foci in one or more organs, occurring synchronously or metachronously, due to fibro-inflammatory changes with hypersecretion of immunoglobulin G subclass 4 (IgG4) in tissues and/or blood serum. Diabetes mellitus (DM) develops among 43-68% of patients with IgG4-related pancreatitis. Diabetes against the background of IgG4-RD can be caused both by damage to the endocrine part of the pancreas and the use of glucocorticosteroids, but its course is moderate, with a rare need for insulin therapy. In both cases, the use of genetically engineered biological therapy with rituximab may be accompanied by an improvement in carbohydrate metabolism. This article describes the course of diabetes and the need for hypoglycemic therapy for 1.5 years in a patient treated with IgG4-RD.https://www.dia-endojournals.ru/jour/article/view/13054igg4 related diseasediabetes mellitusautoimmune pancreatitisglucocorticoidsrituximab |
| spellingShingle | T. S. Panevin A. V. Torgashina A. A. Movsesyan Features of the course of diabetes mellitus in IgG4-associated disease Сахарный диабет igg4 related disease diabetes mellitus autoimmune pancreatitis glucocorticoids rituximab |
| title | Features of the course of diabetes mellitus in IgG4-associated disease |
| title_full | Features of the course of diabetes mellitus in IgG4-associated disease |
| title_fullStr | Features of the course of diabetes mellitus in IgG4-associated disease |
| title_full_unstemmed | Features of the course of diabetes mellitus in IgG4-associated disease |
| title_short | Features of the course of diabetes mellitus in IgG4-associated disease |
| title_sort | features of the course of diabetes mellitus in igg4 associated disease |
| topic | igg4 related disease diabetes mellitus autoimmune pancreatitis glucocorticoids rituximab |
| url | https://www.dia-endojournals.ru/jour/article/view/13054 |
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