Incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myeloma
Abstract Acute kidney injury (AKI) is a common complication after allogeneic stem cell transplantation; however, its incidence and outcome in patients transplanted for multiple myeloma (MM) is unknown. We evaluated the incidence, severity, and risk factors for AKI within the first 30 days after auto...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-06-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.2187 |
| _version_ | 1818421078507126784 |
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| author | Andreea G. Andronesi Alina D. Tanase Bogdan M. Sorohan Oana G. Craciun Laura Stefan Zsofia Varady Lavinia Lipan Bogdan Obrisca Alexandra Truica Gener Ismail |
| author_facet | Andreea G. Andronesi Alina D. Tanase Bogdan M. Sorohan Oana G. Craciun Laura Stefan Zsofia Varady Lavinia Lipan Bogdan Obrisca Alexandra Truica Gener Ismail |
| author_sort | Andreea G. Andronesi |
| collection | DOAJ |
| description | Abstract Acute kidney injury (AKI) is a common complication after allogeneic stem cell transplantation; however, its incidence and outcome in patients transplanted for multiple myeloma (MM) is unknown. We evaluated the incidence, severity, and risk factors for AKI within the first 30 days after autologous stem cell transplantation (ASCT) for MM. We prospectively followed 185 consecutive patients with MM, without chronic renal replacement therapy, who underwent ASCT; 12.5% of patients had MM‐associated amyloidosis. AKI occurred in 19 (10.3%) patients, 8 ± 3 days after ASCT, with 18 patients (9.7%) stage 1 and one patient (0.6%) stage 2 AKI. The development of AKI was not associated with reduced overall survival and recovery of kidney function was evident in 68.4% of patients at 3 months. In Cox regression analysis, preexisting–chronic kidney disease (HR 7.01, CI 95% 2.04‐24.09; P = 0.002), serum beta2 microglobulin (HR 3.05, CI 95% 1.10‐8.44; P = 0.03), and mucositis grade 3/4 (HR 1.29, CI 95% 1.08‐1.53; P = 0.003) were independent risk factors for AKI. Our results suggest that AKI occurs with low incidence and reduced severity after ASCT for MM. Prophylactic measures in patients with preexisting–kidney failure may further reduce this risk. |
| first_indexed | 2024-12-14T13:04:38Z |
| format | Article |
| id | doaj.art-88d9f6e2860c4cc89b61ea76e56969d3 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-14T13:04:38Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-88d9f6e2860c4cc89b61ea76e56969d32022-12-21T23:00:20ZengWileyCancer Medicine2045-76342019-06-01863278328510.1002/cam4.2187Incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myelomaAndreea G. Andronesi0Alina D. Tanase1Bogdan M. Sorohan2Oana G. Craciun3Laura Stefan4Zsofia Varady5Lavinia Lipan6Bogdan Obrisca7Alexandra Truica8Gener Ismail9Nephrology Department Fundeni Clinical Institute Bucharest RomaniaBone Marrow Transplant Department Fundeni Clinical Institute Bucharest RomaniaNephrology Department Fundeni Clinical Institute Bucharest RomaniaBone Marrow Transplant Department Fundeni Clinical Institute Bucharest RomaniaBone Marrow Transplant Department Fundeni Clinical Institute Bucharest RomaniaBone Marrow Transplant Department Fundeni Clinical Institute Bucharest RomaniaBone Marrow Transplant Department Fundeni Clinical Institute Bucharest RomaniaNephrology Department Fundeni Clinical Institute Bucharest RomaniaCarol Davila University of Medicine and Pharmacy Bucharest RomaniaNephrology Department Fundeni Clinical Institute Bucharest RomaniaAbstract Acute kidney injury (AKI) is a common complication after allogeneic stem cell transplantation; however, its incidence and outcome in patients transplanted for multiple myeloma (MM) is unknown. We evaluated the incidence, severity, and risk factors for AKI within the first 30 days after autologous stem cell transplantation (ASCT) for MM. We prospectively followed 185 consecutive patients with MM, without chronic renal replacement therapy, who underwent ASCT; 12.5% of patients had MM‐associated amyloidosis. AKI occurred in 19 (10.3%) patients, 8 ± 3 days after ASCT, with 18 patients (9.7%) stage 1 and one patient (0.6%) stage 2 AKI. The development of AKI was not associated with reduced overall survival and recovery of kidney function was evident in 68.4% of patients at 3 months. In Cox regression analysis, preexisting–chronic kidney disease (HR 7.01, CI 95% 2.04‐24.09; P = 0.002), serum beta2 microglobulin (HR 3.05, CI 95% 1.10‐8.44; P = 0.03), and mucositis grade 3/4 (HR 1.29, CI 95% 1.08‐1.53; P = 0.003) were independent risk factors for AKI. Our results suggest that AKI occurs with low incidence and reduced severity after ASCT for MM. Prophylactic measures in patients with preexisting–kidney failure may further reduce this risk.https://doi.org/10.1002/cam4.2187acute kidney injurymultiple myelomastem cell transplant |
| spellingShingle | Andreea G. Andronesi Alina D. Tanase Bogdan M. Sorohan Oana G. Craciun Laura Stefan Zsofia Varady Lavinia Lipan Bogdan Obrisca Alexandra Truica Gener Ismail Incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myeloma Cancer Medicine acute kidney injury multiple myeloma stem cell transplant |
| title | Incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myeloma |
| title_full | Incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myeloma |
| title_fullStr | Incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myeloma |
| title_full_unstemmed | Incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myeloma |
| title_short | Incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myeloma |
| title_sort | incidence and risk factors for acute kidney injury following autologous stem cell transplantation for multiple myeloma |
| topic | acute kidney injury multiple myeloma stem cell transplant |
| url | https://doi.org/10.1002/cam4.2187 |
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