The Influence of Arginine Methylation in Immunity and Inflammation
Nivine Srour,1,2,* Sarah Khan,1,2,* Stephane Richard1,2 1Segal Cancer Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, H3T 1E2, Canada; 2Gerald Bronfman Department of Oncology, and Departments of Biochemistry, Human Genetics, and Medicine,...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-05-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/the-influence-of-arginine-methylation-in-immunity-and-inflammation-peer-reviewed-fulltext-article-JIR |
| _version_ | 1811233961814261760 |
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| author | Srour N Khan S Richard S |
| author_facet | Srour N Khan S Richard S |
| author_sort | Srour N |
| collection | DOAJ |
| description | Nivine Srour,1,2,* Sarah Khan,1,2,* Stephane Richard1,2 1Segal Cancer Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, H3T 1E2, Canada; 2Gerald Bronfman Department of Oncology, and Departments of Biochemistry, Human Genetics, and Medicine, McGill University, Montréal, Québec, H3T 1E2, Canada*These authors contributed equally to this workCorrespondence: Stephane Richard, Email stephane.richard@mcgill.caAbstract: Exploration in the field of epigenetics has revealed that protein arginine methyltransferases (PRMTs) contribute to disease, and this has given way to the development of specific small molecule compounds that inhibit arginine methylation. Protein arginine methylation is known to regulate fundamental cellular processes, such as transcription; pre-mRNA splicing and other RNA processing mechanisms; signal transduction, including the anti-viral response; and cellular metabolism. PRMTs are also implicated in the regulation of physiological processes, including embryonic development, myogenesis, and the immune system. Finally, the dysregulation of PRMTs is apparent in cancer, neurodegeneration, muscular disorders, and during inflammation. Herein, we review the functions of PRMTs in immunity and inflammation. We also discuss recent progress with PRMTs regarding the modulation of gene expression related to T and B lymphocyte differentiation, germinal center dynamics, and anti-viral signaling responses, as well as the clinical relevance of using PRMT inhibitors alone or in combination with other drugs to treat cancer, immune, and inflammatory-related diseases.Keywords: PRMTs, epigenetics, histones, arginine methylation, immune, inflammation |
| first_indexed | 2024-04-12T11:27:31Z |
| format | Article |
| id | doaj.art-88dc200526874445ac3903964270d774 |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-04-12T11:27:31Z |
| publishDate | 2022-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-88dc200526874445ac3903964270d7742022-12-22T03:35:09ZengDove Medical PressJournal of Inflammation Research1178-70312022-05-01Volume 152939295875271The Influence of Arginine Methylation in Immunity and InflammationSrour NKhan SRichard SNivine Srour,1,2,* Sarah Khan,1,2,* Stephane Richard1,2 1Segal Cancer Centre, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Québec, H3T 1E2, Canada; 2Gerald Bronfman Department of Oncology, and Departments of Biochemistry, Human Genetics, and Medicine, McGill University, Montréal, Québec, H3T 1E2, Canada*These authors contributed equally to this workCorrespondence: Stephane Richard, Email stephane.richard@mcgill.caAbstract: Exploration in the field of epigenetics has revealed that protein arginine methyltransferases (PRMTs) contribute to disease, and this has given way to the development of specific small molecule compounds that inhibit arginine methylation. Protein arginine methylation is known to regulate fundamental cellular processes, such as transcription; pre-mRNA splicing and other RNA processing mechanisms; signal transduction, including the anti-viral response; and cellular metabolism. PRMTs are also implicated in the regulation of physiological processes, including embryonic development, myogenesis, and the immune system. Finally, the dysregulation of PRMTs is apparent in cancer, neurodegeneration, muscular disorders, and during inflammation. Herein, we review the functions of PRMTs in immunity and inflammation. We also discuss recent progress with PRMTs regarding the modulation of gene expression related to T and B lymphocyte differentiation, germinal center dynamics, and anti-viral signaling responses, as well as the clinical relevance of using PRMT inhibitors alone or in combination with other drugs to treat cancer, immune, and inflammatory-related diseases.Keywords: PRMTs, epigenetics, histones, arginine methylation, immune, inflammationhttps://www.dovepress.com/the-influence-of-arginine-methylation-in-immunity-and-inflammation-peer-reviewed-fulltext-article-JIRprmtsepigeneticshistonesarginine methylationimmuneinflammation |
| spellingShingle | Srour N Khan S Richard S The Influence of Arginine Methylation in Immunity and Inflammation Journal of Inflammation Research prmts epigenetics histones arginine methylation immune inflammation |
| title | The Influence of Arginine Methylation in Immunity and Inflammation |
| title_full | The Influence of Arginine Methylation in Immunity and Inflammation |
| title_fullStr | The Influence of Arginine Methylation in Immunity and Inflammation |
| title_full_unstemmed | The Influence of Arginine Methylation in Immunity and Inflammation |
| title_short | The Influence of Arginine Methylation in Immunity and Inflammation |
| title_sort | influence of arginine methylation in immunity and inflammation |
| topic | prmts epigenetics histones arginine methylation immune inflammation |
| url | https://www.dovepress.com/the-influence-of-arginine-methylation-in-immunity-and-inflammation-peer-reviewed-fulltext-article-JIR |
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