The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers
Introduction and objective Biomarkers are measurable biological indicators of many disease states. Particularly noteworthy are short nucleotide sequences involved in the regulation of many cellular processes. Their level in body fluids constitutes an important biological marker of serious diseases,...
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| Format: | Article |
| Language: | English |
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Institute of Rural Health
2021-06-01
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| Series: | Journal of Pre-Clinical and Clinical Research |
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| Online Access: | https://www.jpccr.eu/The-role-of-microRNA-miRNA-as-a-biomarker-in-HPV-and-EBV-related-cancers,138306,0,2.html |
| _version_ | 1797870250976346112 |
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| author | Marcin Koleśnik Ewa Stępień Małgorzata Polz-Dacewicz |
| author_facet | Marcin Koleśnik Ewa Stępień Małgorzata Polz-Dacewicz |
| author_sort | Marcin Koleśnik |
| collection | DOAJ |
| description | Introduction and objective
Biomarkers are measurable biological indicators of many disease states. Particularly noteworthy are short nucleotide sequences involved in the regulation of many cellular processes. Their level in body fluids constitutes an important biological marker of serious diseases, such as cancer or cardiovascular diseases. For example, different types of microRNA may be used as biomarker in virus-associated cancers. The aim of this article was to review the current knowledge on the miRNAs and their role in viral-related cancers (EBV and HPV). The article reviews information available in journals and on electronic databases.
Brief description of the state of knowledge
A significant part of the world’s population hosts at least one of the oncoviruses, but only a small percentage of them undergo a cancerogenesis to which these infectious agents contribute. Interaction between the host cell and viral factors can lead to the origination of a microenvironment favourable to oncogenesis. Cancer arises as a result of dysregulation in many cellular processes, and particularly important are short RNA sequences which regulate the processes that can cause this disease. The varied expression of this ribonucleic acid contributes to many diseases and provides valuable information about health. Importantly, these molecules are differentially expressed in virally-induced cancer. Many publications have confirmed the relationship between the expression of specific types of miRNA and cancers associated with EBV and HPV.
Conclusions
The use of miRNAs as biomarkers of neoplastic diseases associated with EBV and HPV infections may significantly contribute to the reduction of mortality caused by these viruses, and thanks to the development of modern technologies they are an attractive research object |
| first_indexed | 2024-04-10T00:25:29Z |
| format | Article |
| id | doaj.art-88dc829536714c96b0457900e16ecab9 |
| institution | Directory Open Access Journal |
| issn | 1898-2395 1898-7516 |
| language | English |
| last_indexed | 2024-04-10T00:25:29Z |
| publishDate | 2021-06-01 |
| publisher | Institute of Rural Health |
| record_format | Article |
| series | Journal of Pre-Clinical and Clinical Research |
| spelling | doaj.art-88dc829536714c96b0457900e16ecab92023-03-15T10:41:27ZengInstitute of Rural HealthJournal of Pre-Clinical and Clinical Research1898-23951898-75162021-06-0115210411010.26444/jpccr/138306138306The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancersMarcin Koleśnik0https://orcid.org/0000-0002-0400-7416Ewa Stępień1https://orcid.org/0000-0002-9024-8602Małgorzata Polz-Dacewicz2https://orcid.org/0000-0002-3222-184XMedical University, Lublin, PolandMedical University, Lublin, PolandMedical University, Lublin, PolandIntroduction and objective Biomarkers are measurable biological indicators of many disease states. Particularly noteworthy are short nucleotide sequences involved in the regulation of many cellular processes. Their level in body fluids constitutes an important biological marker of serious diseases, such as cancer or cardiovascular diseases. For example, different types of microRNA may be used as biomarker in virus-associated cancers. The aim of this article was to review the current knowledge on the miRNAs and their role in viral-related cancers (EBV and HPV). The article reviews information available in journals and on electronic databases. Brief description of the state of knowledge A significant part of the world’s population hosts at least one of the oncoviruses, but only a small percentage of them undergo a cancerogenesis to which these infectious agents contribute. Interaction between the host cell and viral factors can lead to the origination of a microenvironment favourable to oncogenesis. Cancer arises as a result of dysregulation in many cellular processes, and particularly important are short RNA sequences which regulate the processes that can cause this disease. The varied expression of this ribonucleic acid contributes to many diseases and provides valuable information about health. Importantly, these molecules are differentially expressed in virally-induced cancer. Many publications have confirmed the relationship between the expression of specific types of miRNA and cancers associated with EBV and HPV. Conclusions The use of miRNAs as biomarkers of neoplastic diseases associated with EBV and HPV infections may significantly contribute to the reduction of mortality caused by these viruses, and thanks to the development of modern technologies they are an attractive research objecthttps://www.jpccr.eu/The-role-of-microRNA-miRNA-as-a-biomarker-in-HPV-and-EBV-related-cancers,138306,0,2.htmlcancerbiomarkersmicrornahpvebv |
| spellingShingle | Marcin Koleśnik Ewa Stępień Małgorzata Polz-Dacewicz The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers Journal of Pre-Clinical and Clinical Research cancer biomarkers microrna hpv ebv |
| title | The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers |
| title_full | The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers |
| title_fullStr | The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers |
| title_full_unstemmed | The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers |
| title_short | The role of microRNA (miRNA) as a biomarker in HPV and EBV-related cancers |
| title_sort | role of microrna mirna as a biomarker in hpv and ebv related cancers |
| topic | cancer biomarkers microrna hpv ebv |
| url | https://www.jpccr.eu/The-role-of-microRNA-miRNA-as-a-biomarker-in-HPV-and-EBV-related-cancers,138306,0,2.html |
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