Localized scleroderma in a newborn (case report)
<p> N.I. Akhmina<sup>1</sup>, P.S. Utkin<sup>2</sup>, M.P. Shalatonin<sup>3</sup>, Zh.L. Chabaidze<sup>1</sup>, A.A. Dement’ev<sup>1</sup>, A.L. Zaplatnikov<sup>1</sup> </p> <p> <sup>1</sup>Russi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LCC «Medicine-Inform»
2022-05-01
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| Series: | РМЖ. Мать и дитя |
| Online Access: | http://wchjournal.com/upload/iblock/d00/d006bca45b8eafed64b29f0013bf3fe1.pdf |
| _version_ | 1827341340190441472 |
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| author | N.I. Akhmina P.S. Utkin M.P. Shalatonin Zh.L. Chabaidze A.A. Dementiev A.L. Zaplatnikov |
| author_facet | N.I. Akhmina P.S. Utkin M.P. Shalatonin Zh.L. Chabaidze A.A. Dementiev A.L. Zaplatnikov |
| author_sort | N.I. Akhmina |
| collection | DOAJ |
| description | <p>
N.I. Akhmina<sup>1</sup>, P.S. Utkin<sup>2</sup>, M.P. Shalatonin<sup>3</sup>, Zh.L. Chabaidze<sup>1</sup>, A.A. Dement’ev<sup>1</sup>, A.L. Zaplatnikov<sup>1</sup>
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<sup>1</sup>Russian Medical Academy of Continuous Professional Education, Moscow,
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Russian Federation
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<sup>2</sup>Children’s Infectious Clinical Hospital No. 6, Moscow, Russian Federation
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<sup>3</sup>Morozov Children’s City Clinical Hospital, Moscow, Russian Federation
</p>
<p>
Scleroderma is a rare condition in pediatrics although it ranks third (after juvenile idiopathic arthritis and systemic lupus erythematosus) among rheumatic diseases in children. Congenital scleroderma is considered casuistic since only single case reports are available in publications worldwide. The etiology of congenital scleroderma remains elusive. The principal pathogenic mechanisms are vascular network impairment, immune system dysfunction with abnormal regulation of cytokine release and altered collagen synthesis with fibroblast proliferation and fibrosis. This paper describes a newborn girl with congenital localized nodular scleroderma whose clinical presentations were detected at birth. The authors discuss difficulties with the diagnosis based on clinical and routine lab and instrumental tests. The role of modern morphological studies (given the lack of specific lab tests) to diagnose scleroderma in a newborn is emphasized. Finally, this paper provides a brief review of published data on congenital scleroderma.
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<b>Keywords: </b>congenital scleroderma, children, diagnostics, differential diagnosis, morphological studies.
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<b>For citation:</b> Akhmina N.I., Utkin P.S., Shalatonin M.P. et al. Localized scleroderma in a newborn (case report). Russian Journal of Woman and Child Health. 2022;5(2):169–172 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-169-172.
</p> |
| first_indexed | 2024-03-07T21:38:38Z |
| format | Article |
| id | doaj.art-88dd0625540647289d1eaeb1ff135777 |
| institution | Directory Open Access Journal |
| issn | 2618-8430 2686-7184 |
| language | Russian |
| last_indexed | 2024-03-07T21:38:38Z |
| publishDate | 2022-05-01 |
| publisher | LCC «Medicine-Inform» |
| record_format | Article |
| series | РМЖ. Мать и дитя |
| spelling | doaj.art-88dd0625540647289d1eaeb1ff1357772024-02-26T10:13:33ZrusLCC «Medicine-Inform»РМЖ. Мать и дитя2618-84302686-71842022-05-015233595Localized scleroderma in a newborn (case report)N.I. Akhmina0P.S. Utkin1M.P. Shalatonin2Zh.L. Chabaidze3A.A. Dementiev4A.L. Zaplatnikov5Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399Russian Journal of Woman and Child Health, Publisher of «Medicina-Inform» Address for correspondence: Russia, 105064, Moscow, P.O. Box 399<p> N.I. Akhmina<sup>1</sup>, P.S. Utkin<sup>2</sup>, M.P. Shalatonin<sup>3</sup>, Zh.L. Chabaidze<sup>1</sup>, A.A. Dement’ev<sup>1</sup>, A.L. Zaplatnikov<sup>1</sup> </p> <p> <sup>1</sup>Russian Medical Academy of Continuous Professional Education, Moscow, </p> <p> Russian Federation </p> <p> <sup>2</sup>Children’s Infectious Clinical Hospital No. 6, Moscow, Russian Federation </p> <p> <sup>3</sup>Morozov Children’s City Clinical Hospital, Moscow, Russian Federation </p> <p> Scleroderma is a rare condition in pediatrics although it ranks third (after juvenile idiopathic arthritis and systemic lupus erythematosus) among rheumatic diseases in children. Congenital scleroderma is considered casuistic since only single case reports are available in publications worldwide. The etiology of congenital scleroderma remains elusive. The principal pathogenic mechanisms are vascular network impairment, immune system dysfunction with abnormal regulation of cytokine release and altered collagen synthesis with fibroblast proliferation and fibrosis. This paper describes a newborn girl with congenital localized nodular scleroderma whose clinical presentations were detected at birth. The authors discuss difficulties with the diagnosis based on clinical and routine lab and instrumental tests. The role of modern morphological studies (given the lack of specific lab tests) to diagnose scleroderma in a newborn is emphasized. Finally, this paper provides a brief review of published data on congenital scleroderma. </p> <p> <b>Keywords: </b>congenital scleroderma, children, diagnostics, differential diagnosis, morphological studies. </p> <p> <b>For citation:</b> Akhmina N.I., Utkin P.S., Shalatonin M.P. et al. Localized scleroderma in a newborn (case report). Russian Journal of Woman and Child Health. 2022;5(2):169–172 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-169-172. </p>http://wchjournal.com/upload/iblock/d00/d006bca45b8eafed64b29f0013bf3fe1.pdf |
| spellingShingle | N.I. Akhmina P.S. Utkin M.P. Shalatonin Zh.L. Chabaidze A.A. Dementiev A.L. Zaplatnikov Localized scleroderma in a newborn (case report) РМЖ. Мать и дитя |
| title | Localized scleroderma in a newborn (case report) |
| title_full | Localized scleroderma in a newborn (case report) |
| title_fullStr | Localized scleroderma in a newborn (case report) |
| title_full_unstemmed | Localized scleroderma in a newborn (case report) |
| title_short | Localized scleroderma in a newborn (case report) |
| title_sort | localized scleroderma in a newborn case report |
| url | http://wchjournal.com/upload/iblock/d00/d006bca45b8eafed64b29f0013bf3fe1.pdf |
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