Delivered dose to scrotum in rectal cancer radiotherapy by thermoluminescence dosimetry comparing to dose calculated by planning software
Background: Colorectal carcinoma is a common malignancy, in treatment of which pelvic radiotherapy plays an important role. But this may lead to azospermia. We designed a study to determine the delivered dose to the testis with thermoluminescence dosimetry (TLD) and compare it to the dose calculated...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | fas |
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Tehran University of Medical Sciences
2014-02-01
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| Series: | Tehran University Medical Journal |
| Subjects: | |
| Online Access: | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5164&slc_lang=en&sid=1 |
| _version_ | 1818475448974180352 |
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| author | Peiman Haddad Zhaleh Karimimoghaddam Farshid Farhan Mahbod Esfahani Mahdieh Afkhami Farnaz Amouzegar-Hashemi |
| author_facet | Peiman Haddad Zhaleh Karimimoghaddam Farshid Farhan Mahbod Esfahani Mahdieh Afkhami Farnaz Amouzegar-Hashemi |
| author_sort | Peiman Haddad |
| collection | DOAJ |
| description | Background: Colorectal carcinoma is a common malignancy, in treatment of which pelvic radiotherapy plays an important role. But this may lead to azospermia. We designed a study to determine the delivered dose to the testis with thermoluminescence dosimetry (TLD) and compare it to the dose calculated by the Three-dimensional planning software.
Methods: We measured the testicular doses by TLD; the TLDs were fixed to the scrotum in six points anteriorly and posteriorly in two random fractions of the radiation course. All patients received a 50-50.4 Gy radiation dose to the pelvis in a prone position with standard fractionation and 3-dimensional planning, through three or four fields. The average dose of the TLD measurements was compared to the average of 6 relevant point doses calculated by the planning software.
Results: In 33 patients with a mean age of 56 years, the mean testis dose of radiation measured by TLD was 3.77 Gy, equal to 7.5% of the total prescribed dose. The mean of point doses calculated by the 3-dimensional planning software was 4.11 Gy, equal to 8.1% of the total prescribed dose. A significant relationship was seen between the position of the inferior edge of the fields and the mean testis dose (P= 0.04). Also body mass index (BMI) was inversely related with the testicular dose (P= 0.049).
Conclusion: In this study, the mean testis dose of radiation was 3.77 Gy, similar to the dose calculated by the planning software (4.11 Gy). This dose could be significantly harmful for spermatogenesis, though low doses of scattered radiation to the testis in fractionated radiotherapy might be followed with better recovery. Based on above findings, careful attention to testicular dose in radiotherapy of rectal cancer for the males desiring continued fertility seems to be required. |
| first_indexed | 2024-12-10T09:12:43Z |
| format | Article |
| id | doaj.art-88de92c80a0f46a4943699bf65c264ac |
| institution | Directory Open Access Journal |
| issn | 1683-1764 1735-7322 |
| language | fas |
| last_indexed | 2024-12-10T09:12:43Z |
| publishDate | 2014-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Tehran University Medical Journal |
| spelling | doaj.art-88de92c80a0f46a4943699bf65c264ac2022-12-22T01:54:58ZfasTehran University of Medical SciencesTehran University Medical Journal1683-17641735-73222014-02-017111707712Delivered dose to scrotum in rectal cancer radiotherapy by thermoluminescence dosimetry comparing to dose calculated by planning softwarePeiman Haddad 0Zhaleh Karimimoghaddam 1Farshid Farhan 2Mahbod Esfahani 3Mahdieh Afkhami 4Farnaz Amouzegar-Hashemi5 Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. Department of Radiation Physics, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. Department of Radiation Physics, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. Department of Radiation Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran. Background: Colorectal carcinoma is a common malignancy, in treatment of which pelvic radiotherapy plays an important role. But this may lead to azospermia. We designed a study to determine the delivered dose to the testis with thermoluminescence dosimetry (TLD) and compare it to the dose calculated by the Three-dimensional planning software. Methods: We measured the testicular doses by TLD; the TLDs were fixed to the scrotum in six points anteriorly and posteriorly in two random fractions of the radiation course. All patients received a 50-50.4 Gy radiation dose to the pelvis in a prone position with standard fractionation and 3-dimensional planning, through three or four fields. The average dose of the TLD measurements was compared to the average of 6 relevant point doses calculated by the planning software. Results: In 33 patients with a mean age of 56 years, the mean testis dose of radiation measured by TLD was 3.77 Gy, equal to 7.5% of the total prescribed dose. The mean of point doses calculated by the 3-dimensional planning software was 4.11 Gy, equal to 8.1% of the total prescribed dose. A significant relationship was seen between the position of the inferior edge of the fields and the mean testis dose (P= 0.04). Also body mass index (BMI) was inversely related with the testicular dose (P= 0.049). Conclusion: In this study, the mean testis dose of radiation was 3.77 Gy, similar to the dose calculated by the planning software (4.11 Gy). This dose could be significantly harmful for spermatogenesis, though low doses of scattered radiation to the testis in fractionated radiotherapy might be followed with better recovery. Based on above findings, careful attention to testicular dose in radiotherapy of rectal cancer for the males desiring continued fertility seems to be required.http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5164&slc_lang=en&sid=1azospermia radiotherapy rectal carcinoma testicular radiation dose |
| spellingShingle | Peiman Haddad Zhaleh Karimimoghaddam Farshid Farhan Mahbod Esfahani Mahdieh Afkhami Farnaz Amouzegar-Hashemi Delivered dose to scrotum in rectal cancer radiotherapy by thermoluminescence dosimetry comparing to dose calculated by planning software Tehran University Medical Journal azospermia radiotherapy rectal carcinoma testicular radiation dose |
| title | Delivered dose to scrotum in rectal cancer radiotherapy by thermoluminescence dosimetry comparing to dose calculated by planning software |
| title_full | Delivered dose to scrotum in rectal cancer radiotherapy by thermoluminescence dosimetry comparing to dose calculated by planning software |
| title_fullStr | Delivered dose to scrotum in rectal cancer radiotherapy by thermoluminescence dosimetry comparing to dose calculated by planning software |
| title_full_unstemmed | Delivered dose to scrotum in rectal cancer radiotherapy by thermoluminescence dosimetry comparing to dose calculated by planning software |
| title_short | Delivered dose to scrotum in rectal cancer radiotherapy by thermoluminescence dosimetry comparing to dose calculated by planning software |
| title_sort | delivered dose to scrotum in rectal cancer radiotherapy by thermoluminescence dosimetry comparing to dose calculated by planning software |
| topic | azospermia radiotherapy rectal carcinoma testicular radiation dose |
| url | http://tumj.tums.ac.ir/browse.php?a_code=A-10-25-5164&slc_lang=en&sid=1 |
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