The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism
Obesity and type 2 diabetes are chronic metabolic diseases that impact tens to hundreds of millions of adults, especially in developed countries. Each condition is associated with an elevated risk of breast cancer and with a poor prognosis after treatment. The mechanisms connecting poor metabolic he...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1217875/full |
| _version_ | 1797679239300907008 |
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| author | Barbara Mensah Sankofi Estefania Valencia-Rincón Malika Sekhri Adriana L. Ponton-Almodovar Adriana L. Ponton-Almodovar Adriana L. Ponton-Almodovar Jamie J. Bernard Jamie J. Bernard Jamie J. Bernard Elizabeth A. Wellberg |
| author_facet | Barbara Mensah Sankofi Estefania Valencia-Rincón Malika Sekhri Adriana L. Ponton-Almodovar Adriana L. Ponton-Almodovar Adriana L. Ponton-Almodovar Jamie J. Bernard Jamie J. Bernard Jamie J. Bernard Elizabeth A. Wellberg |
| author_sort | Barbara Mensah Sankofi |
| collection | DOAJ |
| description | Obesity and type 2 diabetes are chronic metabolic diseases that impact tens to hundreds of millions of adults, especially in developed countries. Each condition is associated with an elevated risk of breast cancer and with a poor prognosis after treatment. The mechanisms connecting poor metabolic health to breast cancer are numerous and include hyperinsulinemia, inflammation, excess nutrient availability, and adipose tissue dysfunction. Here, we focus on adipose tissue, highlighting important roles for both adipocytes and fibroblasts in breast cancer progression. One potentially important mediator of adipose tissue effects on breast cancer is the fibroblast growth factor receptor (FGFR) signaling network. Among the many roles of FGFR signaling, we postulate that key mechanisms driving aggressive breast cancer include epithelial-to-mesenchymal transition and cellular metabolic reprogramming. We also pose existing questions that may help better understand breast cancer biology in people with obesity, type 2 diabetes, and poor metabolic health. |
| first_indexed | 2024-03-11T23:11:37Z |
| format | Article |
| id | doaj.art-88e1b3d381f34e7baedfd133c9779c81 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T23:11:37Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-88e1b3d381f34e7baedfd133c9779c812023-09-21T08:32:56ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-09-011410.3389/fendo.2023.12178751217875The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolismBarbara Mensah Sankofi0Estefania Valencia-Rincón1Malika Sekhri2Adriana L. Ponton-Almodovar3Adriana L. Ponton-Almodovar4Adriana L. Ponton-Almodovar5Jamie J. Bernard6Jamie J. Bernard7Jamie J. Bernard8Elizabeth A. Wellberg9Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United StatesNicolas V. Perricone Division of Dermatology, Michigan State University, East Lansing, MI, United StatesDepartment of Medicine, Michigan State University, East Lansing, MI, United StatesDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United StatesNicolas V. Perricone Division of Dermatology, Michigan State University, East Lansing, MI, United StatesDepartment of Medicine, Michigan State University, East Lansing, MI, United StatesDepartment of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United StatesObesity and type 2 diabetes are chronic metabolic diseases that impact tens to hundreds of millions of adults, especially in developed countries. Each condition is associated with an elevated risk of breast cancer and with a poor prognosis after treatment. The mechanisms connecting poor metabolic health to breast cancer are numerous and include hyperinsulinemia, inflammation, excess nutrient availability, and adipose tissue dysfunction. Here, we focus on adipose tissue, highlighting important roles for both adipocytes and fibroblasts in breast cancer progression. One potentially important mediator of adipose tissue effects on breast cancer is the fibroblast growth factor receptor (FGFR) signaling network. Among the many roles of FGFR signaling, we postulate that key mechanisms driving aggressive breast cancer include epithelial-to-mesenchymal transition and cellular metabolic reprogramming. We also pose existing questions that may help better understand breast cancer biology in people with obesity, type 2 diabetes, and poor metabolic health.https://www.frontiersin.org/articles/10.3389/fendo.2023.1217875/fullbreast canceradiposefibroblast growth factorobesitydiabetes |
| spellingShingle | Barbara Mensah Sankofi Estefania Valencia-Rincón Malika Sekhri Adriana L. Ponton-Almodovar Adriana L. Ponton-Almodovar Adriana L. Ponton-Almodovar Jamie J. Bernard Jamie J. Bernard Jamie J. Bernard Elizabeth A. Wellberg The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism Frontiers in Endocrinology breast cancer adipose fibroblast growth factor obesity diabetes |
| title | The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism |
| title_full | The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism |
| title_fullStr | The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism |
| title_full_unstemmed | The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism |
| title_short | The impact of poor metabolic health on aggressive breast cancer: adipose tissue and tumor metabolism |
| title_sort | impact of poor metabolic health on aggressive breast cancer adipose tissue and tumor metabolism |
| topic | breast cancer adipose fibroblast growth factor obesity diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1217875/full |
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