Directed functional connectivity of the default-mode-network of young and older healthy subjects
Abstract Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations with a battery of neuropsychological tests, to understand the differences of DMN directed connectivity between young and older subjects. Using a no...
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| Format: | Article |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-54802-6 |
| _version_ | 1797274730105929728 |
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| author | Gadi Goelman Rotem Dan Ondrej Bezdicek Robert Jech Dana Ekstein |
| author_facet | Gadi Goelman Rotem Dan Ondrej Bezdicek Robert Jech Dana Ekstein |
| author_sort | Gadi Goelman |
| collection | DOAJ |
| description | Abstract Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations with a battery of neuropsychological tests, to understand the differences of DMN directed connectivity between young and older subjects. Using a novel multivariate analysis method on resting-state functional MRI data from fifty young and thirty-one healthy older subjects, we calculated intra- and inter-DMN 4-nodes directed pathways. For the old subject group, we calculated the partial correlations of inter-DMN pathways with: psychomotor speed and working memory, executive function, language, long-term memory and visuospatial function. Pathways connecting the DMN with visual and limbic regions in older subjects engaged at BOLD low frequency and involved the dorsal posterior cingulate cortex (PCC), whereas in young subjects, they were at high frequency and involved the ventral PCC. Pathways combining the sensorimotor (SM) cortex and the DMN, were SM efferent in the young subjects and SM afferent in the older subjects. Most DMN efferent pathways correlated with reduced speed and working memory. We suggest that the reduced sensorimotor efferent and the increased need to control such activities, cause a higher dependency on external versus internal cues thus suggesting how physical activity might slow aging. |
| first_indexed | 2024-03-07T15:03:27Z |
| format | Article |
| id | doaj.art-88e1cbd3b2a34392b5620b4820ef7334 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:03:27Z |
| publishDate | 2024-02-01 |
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| series | Scientific Reports |
| spelling | doaj.art-88e1cbd3b2a34392b5620b4820ef73342024-03-05T19:02:38ZengNature PortfolioScientific Reports2045-23222024-02-0114111410.1038/s41598-024-54802-6Directed functional connectivity of the default-mode-network of young and older healthy subjectsGadi Goelman0Rotem Dan1Ondrej Bezdicek2Robert Jech3Dana Ekstein4Department of Neurology, Ginges Center of Neurogenetics, Hadassah Hebrew University Medical CenterDepartment of Neurology, Ginges Center of Neurogenetics, Hadassah Hebrew University Medical CenterDepartment of Neurology and Center of Clinical Neuroscience, Charles UniversityDepartment of Neurology and Center of Clinical Neuroscience, Charles UniversityDepartment of Neurology, Ginges Center of Neurogenetics, Hadassah Hebrew University Medical CenterAbstract Alterations in the default mode network (DMN) are associated with aging. We assessed age-dependent changes of DMN interactions and correlations with a battery of neuropsychological tests, to understand the differences of DMN directed connectivity between young and older subjects. Using a novel multivariate analysis method on resting-state functional MRI data from fifty young and thirty-one healthy older subjects, we calculated intra- and inter-DMN 4-nodes directed pathways. For the old subject group, we calculated the partial correlations of inter-DMN pathways with: psychomotor speed and working memory, executive function, language, long-term memory and visuospatial function. Pathways connecting the DMN with visual and limbic regions in older subjects engaged at BOLD low frequency and involved the dorsal posterior cingulate cortex (PCC), whereas in young subjects, they were at high frequency and involved the ventral PCC. Pathways combining the sensorimotor (SM) cortex and the DMN, were SM efferent in the young subjects and SM afferent in the older subjects. Most DMN efferent pathways correlated with reduced speed and working memory. We suggest that the reduced sensorimotor efferent and the increased need to control such activities, cause a higher dependency on external versus internal cues thus suggesting how physical activity might slow aging.https://doi.org/10.1038/s41598-024-54802-6AgingDirected functional connectivity MRIDefault mode networkMultivariate analysisNeuropsychological tests |
| spellingShingle | Gadi Goelman Rotem Dan Ondrej Bezdicek Robert Jech Dana Ekstein Directed functional connectivity of the default-mode-network of young and older healthy subjects Scientific Reports Aging Directed functional connectivity MRI Default mode network Multivariate analysis Neuropsychological tests |
| title | Directed functional connectivity of the default-mode-network of young and older healthy subjects |
| title_full | Directed functional connectivity of the default-mode-network of young and older healthy subjects |
| title_fullStr | Directed functional connectivity of the default-mode-network of young and older healthy subjects |
| title_full_unstemmed | Directed functional connectivity of the default-mode-network of young and older healthy subjects |
| title_short | Directed functional connectivity of the default-mode-network of young and older healthy subjects |
| title_sort | directed functional connectivity of the default mode network of young and older healthy subjects |
| topic | Aging Directed functional connectivity MRI Default mode network Multivariate analysis Neuropsychological tests |
| url | https://doi.org/10.1038/s41598-024-54802-6 |
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