Men's health in type 2 diabetes. Focus on metabolic and antioxidant properties of testosterone
Oxidative stress is the pathogenetic basis for the progression of T2DM. It is important to evaluate antioxidant properties of testosterone medications used for the management of male hypogonadism (a comorbidity of T2DM). Aim: to evaluate antioxidant properties of testosterone hormone replacement the...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2016-12-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/61 |
| _version_ | 1797841706010279936 |
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| author | А. S. Ametov L. L. Kamynina O. A. Rozhdestvenskaya E. Y. Pashkova |
| author_facet | А. S. Ametov L. L. Kamynina O. A. Rozhdestvenskaya E. Y. Pashkova |
| author_sort | А. S. Ametov |
| collection | DOAJ |
| description | Oxidative stress is the pathogenetic basis for the progression of T2DM. It is important to evaluate antioxidant properties of testosterone medications used for the management of male hypogonadism (a comorbidity of T2DM). Aim: to evaluate antioxidant properties of testosterone hormone replacement therapy (THRT) in patients with type 2 diabetes. Material and methods: the randomized (1:1) clinical trial included 108 patients with type 2 diabetes, visceral obesity and hypogonadism. The treatment group received THRT for 12 months. The changes in metabolic (glycemic and non-glycemic) parameters and activity of antioxidant protection enzymes - superoxide dismutase (SOD) and glutathione peroxiase, (GPO), were evaluated. The ΔOxS index was suggested to characterize the changes in oxidative stress. Results: THRT was associated with improved metabolic and antioxidant status. Increased SOD and GPO activity against a background of THRT was 32.4 ± 5.6 U/l and 580 ± 68 U/ml, respectively (p < 0.05). ΔOxS was characterized by positive changes only in the treatment group, indicating a decrease in oxidative stress during THRT. Conclusions: in patients with visceral obesity and T2DM, THRT contributed to improvement in metabolic parameters and elimination of oxidative stress and glucose-lypo-toxicity, and that could potentially reduce the risk of progression of type 2 diabetes and its complications. |
| first_indexed | 2024-04-09T16:35:38Z |
| format | Article |
| id | doaj.art-88e1eca983a94c438d38f872b79e9866 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:35:38Z |
| publishDate | 2016-12-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-88e1eca983a94c438d38f872b79e98662023-04-23T06:56:54ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902016-12-0103667110.21518/2079-701X-2016-3-66-7161Men's health in type 2 diabetes. Focus on metabolic and antioxidant properties of testosteroneА. S. Ametov0L. L. Kamynina1O. A. Rozhdestvenskaya2E. Y. Pashkova3Russian Medical Academy of Postgraduate EducationRussian Medical Academy of Postgraduate EducationRussian Medical Academy of Postgraduate EducationScientific Clinical Center of Russian Railways OAOOxidative stress is the pathogenetic basis for the progression of T2DM. It is important to evaluate antioxidant properties of testosterone medications used for the management of male hypogonadism (a comorbidity of T2DM). Aim: to evaluate antioxidant properties of testosterone hormone replacement therapy (THRT) in patients with type 2 diabetes. Material and methods: the randomized (1:1) clinical trial included 108 patients with type 2 diabetes, visceral obesity and hypogonadism. The treatment group received THRT for 12 months. The changes in metabolic (glycemic and non-glycemic) parameters and activity of antioxidant protection enzymes - superoxide dismutase (SOD) and glutathione peroxiase, (GPO), were evaluated. The ΔOxS index was suggested to characterize the changes in oxidative stress. Results: THRT was associated with improved metabolic and antioxidant status. Increased SOD and GPO activity against a background of THRT was 32.4 ± 5.6 U/l and 580 ± 68 U/ml, respectively (p < 0.05). ΔOxS was characterized by positive changes only in the treatment group, indicating a decrease in oxidative stress during THRT. Conclusions: in patients with visceral obesity and T2DM, THRT contributed to improvement in metabolic parameters and elimination of oxidative stress and glucose-lypo-toxicity, and that could potentially reduce the risk of progression of type 2 diabetes and its complications.https://www.med-sovet.pro/jour/article/view/61сахарный диабет 2-го типаокислительный стресссупероксиддисмутазаглутатионпероксидазатестостеронмужское здоровьеtype 2 diabetesoxidative stresssuperoxide dismutaseglutathione peroxidasetestosteronemen's health |
| spellingShingle | А. S. Ametov L. L. Kamynina O. A. Rozhdestvenskaya E. Y. Pashkova Men's health in type 2 diabetes. Focus on metabolic and antioxidant properties of testosterone Медицинский совет сахарный диабет 2-го типа окислительный стресс супероксиддисмутаза глутатионпероксидаза тестостерон мужское здоровье type 2 diabetes oxidative stress superoxide dismutase glutathione peroxidase testosterone men's health |
| title | Men's health in type 2 diabetes. Focus on metabolic and antioxidant properties of testosterone |
| title_full | Men's health in type 2 diabetes. Focus on metabolic and antioxidant properties of testosterone |
| title_fullStr | Men's health in type 2 diabetes. Focus on metabolic and antioxidant properties of testosterone |
| title_full_unstemmed | Men's health in type 2 diabetes. Focus on metabolic and antioxidant properties of testosterone |
| title_short | Men's health in type 2 diabetes. Focus on metabolic and antioxidant properties of testosterone |
| title_sort | men s health in type 2 diabetes focus on metabolic and antioxidant properties of testosterone |
| topic | сахарный диабет 2-го типа окислительный стресс супероксиддисмутаза глутатионпероксидаза тестостерон мужское здоровье type 2 diabetes oxidative stress superoxide dismutase glutathione peroxidase testosterone men's health |
| url | https://www.med-sovet.pro/jour/article/view/61 |
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