Global Methylome Scores Correlate with Histological Subtypes of Colorectal Carcinoma and Show Different Associations with Common Clinical and Molecular Features

Global Methylome Scores Correlate with Histological Subtypes of Colorectal Carcinoma and Show Different Associations with Common Clinical and Molecular Features

Background. The typical methylation patterns associated with cancer are hypermethylation at gene promoters and global genome hypomethylation. Aberrant CpG island hypermethylation at promoter regions and global genome hypomethylation have not been associated with histological colorectal carcinomas (C...

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Bibliographic Details
Main Authors: María del Carmen Turpín-Sevilla, Fernando Pérez-Sanz, José García-Solano, Patricia Sebastián-León, Javier Trujillo-Santos, Pablo Carbonell, Eduardo Estrada, Anne Tuomisto, Irene Herruzo, Lochlan J. Fennell, Markus J. Mäkinen, Edith Rodríguez-Braun, Vicki L. J. Whitehall, Ana Conesa, Pablo Conesa-Zamora
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
colorectal carcinoma
serrated pathway
microsatellite instability
serrated adenocarcinoma
CIMP
DNA methylation
Online Access:https://www.mdpi.com/2072-6694/13/20/5165

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