The Evolution, Spread and Global Threat of H6Nx Avian Influenza Viruses

Avian influenza viruses of the subtype H6Nx are being detected globally with increasing frequency. Some H6Nx lineages are becoming enzootic in Asian poultry and sporadic incursions into European poultry are occurring more frequently. H6Nx viruses that contain mammalian adaptation motifs pose a zoono...

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Main Authors: Holly Everest, Sarah C. Hill, Rebecca Daines, Joshua E. Sealy, Joe James, Rowena Hansen, Munir Iqbal
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Viruses
Subjects:
Online Access:https://www.mdpi.com/1999-4915/12/6/673
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author Holly Everest
Sarah C. Hill
Rebecca Daines
Joshua E. Sealy
Joe James
Rowena Hansen
Munir Iqbal
author_facet Holly Everest
Sarah C. Hill
Rebecca Daines
Joshua E. Sealy
Joe James
Rowena Hansen
Munir Iqbal
author_sort Holly Everest
collection DOAJ
description Avian influenza viruses of the subtype H6Nx are being detected globally with increasing frequency. Some H6Nx lineages are becoming enzootic in Asian poultry and sporadic incursions into European poultry are occurring more frequently. H6Nx viruses that contain mammalian adaptation motifs pose a zoonotic threat and have caused human cases. Although currently understudied globally, H6Nx avian influenza viruses pose a substantial threat to both poultry and human health. In this review we examine the current state of knowledge of H6Nx viruses including their global distribution, tropism, transmission routes and human health risk.
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spelling doaj.art-88e396af2c1c41f89be3f2d0fabf47552023-11-20T04:36:24ZengMDPI AGViruses1999-49152020-06-0112667310.3390/v12060673The Evolution, Spread and Global Threat of H6Nx Avian Influenza VirusesHolly Everest0Sarah C. Hill1Rebecca Daines2Joshua E. Sealy3Joe James4Rowena Hansen5Munir Iqbal6The Pirbright Institute, Woking GU24 0NF, UKDepartment of Zoology, University of Oxford, Oxford OX1 3SZ UKThe Pirbright Institute, Woking GU24 0NF, UKThe Pirbright Institute, Woking GU24 0NF, UKDepartment of Virology, Animal and Plant Health Agency, Addlestone KT15 3NB, UKDepartment of Virology, Animal and Plant Health Agency, Addlestone KT15 3NB, UKThe Pirbright Institute, Woking GU24 0NF, UKAvian influenza viruses of the subtype H6Nx are being detected globally with increasing frequency. Some H6Nx lineages are becoming enzootic in Asian poultry and sporadic incursions into European poultry are occurring more frequently. H6Nx viruses that contain mammalian adaptation motifs pose a zoonotic threat and have caused human cases. Although currently understudied globally, H6Nx avian influenza viruses pose a substantial threat to both poultry and human health. In this review we examine the current state of knowledge of H6Nx viruses including their global distribution, tropism, transmission routes and human health risk.https://www.mdpi.com/1999-4915/12/6/673H6Nxavian influenzazoonoticpandemicpoultryreassortment
spellingShingle Holly Everest
Sarah C. Hill
Rebecca Daines
Joshua E. Sealy
Joe James
Rowena Hansen
Munir Iqbal
The Evolution, Spread and Global Threat of H6Nx Avian Influenza Viruses
Viruses
H6Nx
avian influenza
zoonotic
pandemic
poultry
reassortment
title The Evolution, Spread and Global Threat of H6Nx Avian Influenza Viruses
title_full The Evolution, Spread and Global Threat of H6Nx Avian Influenza Viruses
title_fullStr The Evolution, Spread and Global Threat of H6Nx Avian Influenza Viruses
title_full_unstemmed The Evolution, Spread and Global Threat of H6Nx Avian Influenza Viruses
title_short The Evolution, Spread and Global Threat of H6Nx Avian Influenza Viruses
title_sort evolution spread and global threat of h6nx avian influenza viruses
topic H6Nx
avian influenza
zoonotic
pandemic
poultry
reassortment
url https://www.mdpi.com/1999-4915/12/6/673
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