Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex

Microglial VPS35 deficiency regulates microglial polarization and decreases ischemic stroke-induced damage in the cortex

Abstract Background Vacuolar sorting protein 35 (VPS35), a critical component of retromer, is essential for selective endosome-to-Golgi retrieval of membrane proteins. It is highly expressed in microglial cells, in addition to neurons. We have previously demonstrated microglial VPS35’s functions in...

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Bibliographic Details
Main Authors: Shi-Yang Ye, Joanna E. Apple, Xiao Ren, Fu-Lei Tang, Ling-Ling Yao, Yong-Gang Wang, Lin Mei, Yuan-Guo Zhou, Wen-Cheng Xiong
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
VPS35
Microglia
Ischemic brain injury
CX3CR1
Online Access:http://link.springer.com/article/10.1186/s12974-019-1633-y

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