Clinical Changes and Uterine Hemodynamic in Pyometra Medically Treated Bitches
Cystic endometrial hyperplasia–pyometra complex is a canine endometrial disorder, considered the most common and important among uterine diseases. The treatment of choice is ovariohysterectomy, but medical treatments have become an alternative. However, no studies have been performed in order to eva...
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MDPI AG
2020-10-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/10/11/2011 |
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| author | Roberto Rodrigues da Rosa Filho Maíra Morales Brito Thaís Gomes Faustino Leticia Lima de Almeida Thayná Pantoja Gardés Roberta Ferreira Leite Camila Infantosi Vannucchi |
| author_facet | Roberto Rodrigues da Rosa Filho Maíra Morales Brito Thaís Gomes Faustino Leticia Lima de Almeida Thayná Pantoja Gardés Roberta Ferreira Leite Camila Infantosi Vannucchi |
| author_sort | Roberto Rodrigues da Rosa Filho |
| collection | DOAJ |
| description | Cystic endometrial hyperplasia–pyometra complex is a canine endometrial disorder, considered the most common and important among uterine diseases. The treatment of choice is ovariohysterectomy, but medical treatments have become an alternative. However, no studies have been performed in order to evaluate uterine hemodynamic changes during medical treatment for pyometra bitches. Therefore, the aim of this study was to compare the effectiveness of two medical protocols by means of clinical (heart rate, respiratory rate and body temperature), medullar response (complete blood count (CBC)) and uterine hemodynamic evaluation in pyometra bitches. For such purpose, 10 bitches with pyometra were assigned to two groups: Aglepristone Group (n = 5) and Associative Group (aglepristone + prostaglandin; n = 5). The Associative Group had altered respiratory rate and decreased body temperature. The Aglepristone Group had decreased plasma protein, however, leukocyte count reduced over time for both therapeutic protocols. Uterine area and vascularization score decreased throughout treatment. There was a significant reduction in uterine perimeter, area and vascularization score. The Associative Group had lower final diastolic velocity and higher systole:diastole ratio (S/D), pulsatility index (PI) and resistance index (RI). In conclusion, both medical treatments are effective in reversing clinical and CBC changes of pyometra, especially aglepristone, however they cannot fully restore local uterine changes in a short-term evaluation. Conversely, associative therapy was more effective in decreasing uterine vascularization and modulating uterine blood flow. |
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| language | English |
| last_indexed | 2024-03-10T15:09:53Z |
| publishDate | 2020-10-01 |
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| record_format | Article |
| series | Animals |
| spelling | doaj.art-88eb0d47f58a4046bdc1de691701f2ba2023-11-20T19:25:28ZengMDPI AGAnimals2076-26152020-10-011011201110.3390/ani10112011Clinical Changes and Uterine Hemodynamic in Pyometra Medically Treated BitchesRoberto Rodrigues da Rosa Filho0Maíra Morales Brito1Thaís Gomes Faustino2Leticia Lima de Almeida3Thayná Pantoja Gardés4Roberta Ferreira Leite5Camila Infantosi Vannucchi6Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, BrazilDepartment of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, BrazilDepartment of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, BrazilDepartment of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, BrazilDepartment of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, BrazilDepartment of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, BrazilDepartment of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo 05508-270, BrazilCystic endometrial hyperplasia–pyometra complex is a canine endometrial disorder, considered the most common and important among uterine diseases. The treatment of choice is ovariohysterectomy, but medical treatments have become an alternative. However, no studies have been performed in order to evaluate uterine hemodynamic changes during medical treatment for pyometra bitches. Therefore, the aim of this study was to compare the effectiveness of two medical protocols by means of clinical (heart rate, respiratory rate and body temperature), medullar response (complete blood count (CBC)) and uterine hemodynamic evaluation in pyometra bitches. For such purpose, 10 bitches with pyometra were assigned to two groups: Aglepristone Group (n = 5) and Associative Group (aglepristone + prostaglandin; n = 5). The Associative Group had altered respiratory rate and decreased body temperature. The Aglepristone Group had decreased plasma protein, however, leukocyte count reduced over time for both therapeutic protocols. Uterine area and vascularization score decreased throughout treatment. There was a significant reduction in uterine perimeter, area and vascularization score. The Associative Group had lower final diastolic velocity and higher systole:diastole ratio (S/D), pulsatility index (PI) and resistance index (RI). In conclusion, both medical treatments are effective in reversing clinical and CBC changes of pyometra, especially aglepristone, however they cannot fully restore local uterine changes in a short-term evaluation. Conversely, associative therapy was more effective in decreasing uterine vascularization and modulating uterine blood flow.https://www.mdpi.com/2076-2615/10/11/2011aglepristoneprostaglandinDoppleruterus |
| spellingShingle | Roberto Rodrigues da Rosa Filho Maíra Morales Brito Thaís Gomes Faustino Leticia Lima de Almeida Thayná Pantoja Gardés Roberta Ferreira Leite Camila Infantosi Vannucchi Clinical Changes and Uterine Hemodynamic in Pyometra Medically Treated Bitches Animals aglepristone prostaglandin Doppler uterus |
| title | Clinical Changes and Uterine Hemodynamic in Pyometra Medically Treated Bitches |
| title_full | Clinical Changes and Uterine Hemodynamic in Pyometra Medically Treated Bitches |
| title_fullStr | Clinical Changes and Uterine Hemodynamic in Pyometra Medically Treated Bitches |
| title_full_unstemmed | Clinical Changes and Uterine Hemodynamic in Pyometra Medically Treated Bitches |
| title_short | Clinical Changes and Uterine Hemodynamic in Pyometra Medically Treated Bitches |
| title_sort | clinical changes and uterine hemodynamic in pyometra medically treated bitches |
| topic | aglepristone prostaglandin Doppler uterus |
| url | https://www.mdpi.com/2076-2615/10/11/2011 |
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