Translating phage therapy into the clinic: Recent accomplishments but continuing challenges
Phage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-05-01
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| Series: | PLoS Biology |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204993/?tool=EBI |
| _version_ | 1827940833339375616 |
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| author | Aleksandra Petrovic Fabijan Jonathan Iredell Katarzyna Danis-Wlodarczyk Razieh Kebriaei Stephen T. Abedon |
| author_facet | Aleksandra Petrovic Fabijan Jonathan Iredell Katarzyna Danis-Wlodarczyk Razieh Kebriaei Stephen T. Abedon |
| author_sort | Aleksandra Petrovic Fabijan |
| collection | DOAJ |
| description | Phage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing numbers of clinical case studies being published. This renewed enthusiasm is due in large part to phage therapy holding promise for providing safe and effective cures for bacterial infections that traditional antibiotics acting alone have been unable to clear. This Essay introduces basic phage biology, provides an outline of the long history of phage therapy, highlights some advantages of using phages as antibacterial agents, and provides an overview of recent phage therapy clinical successes. Although phage therapy has clear clinical potential, it faces biological, regulatory, and economic challenges to its further implementation and more mainstream acceptance. Phage therapy employs viruses that specifically infect bacteria to combat bacterial infections, including those infections that do not respond to treatments using traditional antibiotics. Despite being developed 100 years ago, phage therapy is currently experiencing a resurgence in interest, as outlined in this Essay. |
| first_indexed | 2024-03-13T09:28:20Z |
| format | Article |
| id | doaj.art-88ef94b915494f7c8613627e890a44ed |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-03-13T09:28:20Z |
| publishDate | 2023-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-88ef94b915494f7c8613627e890a44ed2023-05-26T05:30:33ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852023-05-01215Translating phage therapy into the clinic: Recent accomplishments but continuing challengesAleksandra Petrovic FabijanJonathan IredellKatarzyna Danis-WlodarczykRazieh KebriaeiStephen T. AbedonPhage therapy is a medical form of biological control of bacterial infections, one that uses naturally occurring viruses, called bacteriophages or phages, as antibacterial agents. Pioneered over 100 years ago, phage therapy nonetheless is currently experiencing a resurgence in interest, with growing numbers of clinical case studies being published. This renewed enthusiasm is due in large part to phage therapy holding promise for providing safe and effective cures for bacterial infections that traditional antibiotics acting alone have been unable to clear. This Essay introduces basic phage biology, provides an outline of the long history of phage therapy, highlights some advantages of using phages as antibacterial agents, and provides an overview of recent phage therapy clinical successes. Although phage therapy has clear clinical potential, it faces biological, regulatory, and economic challenges to its further implementation and more mainstream acceptance. Phage therapy employs viruses that specifically infect bacteria to combat bacterial infections, including those infections that do not respond to treatments using traditional antibiotics. Despite being developed 100 years ago, phage therapy is currently experiencing a resurgence in interest, as outlined in this Essay.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204993/?tool=EBI |
| spellingShingle | Aleksandra Petrovic Fabijan Jonathan Iredell Katarzyna Danis-Wlodarczyk Razieh Kebriaei Stephen T. Abedon Translating phage therapy into the clinic: Recent accomplishments but continuing challenges PLoS Biology |
| title | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
| title_full | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
| title_fullStr | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
| title_full_unstemmed | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
| title_short | Translating phage therapy into the clinic: Recent accomplishments but continuing challenges |
| title_sort | translating phage therapy into the clinic recent accomplishments but continuing challenges |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204993/?tool=EBI |
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