Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature
Abstract Background Simultaneous occurrence of exocrine and neuroendocrine tumors of the pancreas is very infrequent. We report a patient with an endocrine tumor in the pancreatic-duodenal area and extensive exocrine carcinoma involving the whole pancreas. Case presentation A 69-year-old woman was h...
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | World Journal of Surgical Oncology |
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| Online Access: | http://link.springer.com/article/10.1186/s12957-017-1157-9 |
| _version_ | 1818610485495332864 |
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| author | Simone Serafini Gianfranco Da Dalt Gioia Pozza Stella Blandamura Michele Valmasoni Stefano Merigliano Cosimo Sperti |
| author_facet | Simone Serafini Gianfranco Da Dalt Gioia Pozza Stella Blandamura Michele Valmasoni Stefano Merigliano Cosimo Sperti |
| author_sort | Simone Serafini |
| collection | DOAJ |
| description | Abstract Background Simultaneous occurrence of exocrine and neuroendocrine tumors of the pancreas is very infrequent. We report a patient with an endocrine tumor in the pancreatic-duodenal area and extensive exocrine carcinoma involving the whole pancreas. Case presentation A 69-year-old woman was hospitalized in May 2016 for epigastric pain and weight loss. Her past medical history revealed an undefined main pancreatic duct dilation that was subsequently confirmed at CT scan (23 mm) and endoscopic ultrasound. There was no evidence of pancreatic masses, but the cephalic portion of the main pancreatic duct presented hypoechoic nodules. A diagnosis of the main-duct intraductal papillary mucinous neoplasm was made, and the patient underwent total pancreatectomy. Pathological examination showed a collision tumor constituted by a ductal adenocarcinoma involving the whole pancreas and a neuroendocrine tumor located in the duodenal peripancreatic wall and the head of the pancreas. There was one peripancreatic lymph node metastasis from the ductal adenocarcinoma and eight node metastases from the neuroendocrine tumor. These findings suggested a diagnosis of collision of neuroendocrine and ductal adenocarcinomas of the pancreas. The postoperative course was uneventful. Conclusions The coexistence of pancreatic endocrine and exocrine tumors is very uncommon. When present, problems in differential diagnosis may arise between mixed exocrine-endocrine carcinoma or the collision of separate tumors. |
| first_indexed | 2024-12-16T15:15:11Z |
| format | Article |
| id | doaj.art-88eff39b946747899b9d1f85d9568141 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-16T15:15:11Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-88eff39b946747899b9d1f85d95681412022-12-21T22:26:50ZengBMCWorld Journal of Surgical Oncology1477-78192017-05-011511510.1186/s12957-017-1157-9Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literatureSimone Serafini0Gianfranco Da Dalt1Gioia Pozza2Stella Blandamura3Michele Valmasoni4Stefano Merigliano5Cosimo Sperti6Department of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of PaduaDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of PaduaDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of PaduaDepartment of Pathology, University of PaduaDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of PaduaDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of PaduaDepartment of Surgery, Oncology and Gastroenterology, 3rd Surgical Clinic, University of PaduaAbstract Background Simultaneous occurrence of exocrine and neuroendocrine tumors of the pancreas is very infrequent. We report a patient with an endocrine tumor in the pancreatic-duodenal area and extensive exocrine carcinoma involving the whole pancreas. Case presentation A 69-year-old woman was hospitalized in May 2016 for epigastric pain and weight loss. Her past medical history revealed an undefined main pancreatic duct dilation that was subsequently confirmed at CT scan (23 mm) and endoscopic ultrasound. There was no evidence of pancreatic masses, but the cephalic portion of the main pancreatic duct presented hypoechoic nodules. A diagnosis of the main-duct intraductal papillary mucinous neoplasm was made, and the patient underwent total pancreatectomy. Pathological examination showed a collision tumor constituted by a ductal adenocarcinoma involving the whole pancreas and a neuroendocrine tumor located in the duodenal peripancreatic wall and the head of the pancreas. There was one peripancreatic lymph node metastasis from the ductal adenocarcinoma and eight node metastases from the neuroendocrine tumor. These findings suggested a diagnosis of collision of neuroendocrine and ductal adenocarcinomas of the pancreas. The postoperative course was uneventful. Conclusions The coexistence of pancreatic endocrine and exocrine tumors is very uncommon. When present, problems in differential diagnosis may arise between mixed exocrine-endocrine carcinoma or the collision of separate tumors.http://link.springer.com/article/10.1186/s12957-017-1157-9Collision tumorGISTIntraductal papillary mucinous tumorNeuroendocrine tumorPancreatic cancer |
| spellingShingle | Simone Serafini Gianfranco Da Dalt Gioia Pozza Stella Blandamura Michele Valmasoni Stefano Merigliano Cosimo Sperti Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature World Journal of Surgical Oncology Collision tumor GIST Intraductal papillary mucinous tumor Neuroendocrine tumor Pancreatic cancer |
| title | Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature |
| title_full | Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature |
| title_fullStr | Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature |
| title_full_unstemmed | Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature |
| title_short | Collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas: a case report and review of the literature |
| title_sort | collision of ductal adenocarcinoma and neuroendocrine tumor of the pancreas a case report and review of the literature |
| topic | Collision tumor GIST Intraductal papillary mucinous tumor Neuroendocrine tumor Pancreatic cancer |
| url | http://link.springer.com/article/10.1186/s12957-017-1157-9 |
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