Association of Polygenetic Risk Scores Related to Cell Differentiation and Inflammation with Thyroid Cancer Risk and Genetic Interaction with Dietary Intake
The incidence of thyroid cancer continues to increase steadily, and this increasing incidence cannot be attributed solely to the overdiagnosis of microcarcinoma or technical advancements in detection methods and may also depend on environmental and genetic factors. However, the impacts and interacti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/7/1510 |
| _version_ | 1797540096887488512 |
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| author | Sang Shin Song ShaoKai Huang Sunmin Park |
| author_facet | Sang Shin Song ShaoKai Huang Sunmin Park |
| author_sort | Sang Shin Song |
| collection | DOAJ |
| description | The incidence of thyroid cancer continues to increase steadily, and this increasing incidence cannot be attributed solely to the overdiagnosis of microcarcinoma or technical advancements in detection methods and may also depend on environmental and genetic factors. However, the impacts and interactions of genetic and environmental factors remain controversial, and they may differ in Eastern and Western countries. The study’s purpose was to identify single nucleotide polymorphisms of genes related to cell differentiation and inflammation to influence thyroid cancer incidence and determine interactions with lifestyles in a large city hospital-based cohort. Genetic variants were selected by genome-wide association study with thyroid cancer participants (case; <i>n</i> = 495) and controls without cancers (<i>n</i> = 56,439). SNPs having gene–gene interactions were selected by generalized multifactor dimensionality reduction. Polygenic risk scores (PRSs) were generated by summing the number of selected SNP risk alleles. PRSs of the best model included 6 SNPs, that is, <i>DIRC3</i>_rs6759952, <i>GAP43</i>_rs13059137, <i>NRG1</i>_rs7834206, <i>PROM1</i>_rs72616195, <i>LRP1B</i>_rs1369535, and <i>LOC100507065</i>_rs11175834. Participants with a high-PRS had a higher thyroid cancer risk by 3.9-fold than those with a low-PRS. The following variables were related to an increased thyroid cancer risk; female (OR = 4.21), high white blood cell count (OR = 4.03), and high energy (OR = 7.00), low alcohol (OR = 4.11), and high seaweed (OR = 4.02) intakes. These variables also interacted with PRS to influence thyroid cancer risk. Meat/noodle diet patterns interacted with PRSs to increase thyroid cancer risk (<i>p</i> = 0.0023). In conclusion, women with a high-PRS associated with cell differentiation and inflammation were at an elevated thyroid cancer risk. Daily energy, seaweeds, and alcohol intake interacted with PRS for thyroid cancer risk. These results could be applied to personalized nutrition plans to reduce the risk of thyroid cancer. |
| first_indexed | 2024-03-10T12:55:16Z |
| format | Article |
| id | doaj.art-88f0929557c44fdaa6accb394b76926a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T12:55:16Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-88f0929557c44fdaa6accb394b76926a2023-11-21T11:58:35ZengMDPI AGCancers2072-66942021-03-01137151010.3390/cancers13071510Association of Polygenetic Risk Scores Related to Cell Differentiation and Inflammation with Thyroid Cancer Risk and Genetic Interaction with Dietary IntakeSang Shin Song0ShaoKai Huang1Sunmin Park2Obesity/Diabetes Research Center, Department of Food and Nutrition, Hoseo University, Asan 31499, KoreaDepartment of Bio-Convergence System, Hoseo University, Asan 31499, KoreaObesity/Diabetes Research Center, Department of Food and Nutrition, Hoseo University, Asan 31499, KoreaThe incidence of thyroid cancer continues to increase steadily, and this increasing incidence cannot be attributed solely to the overdiagnosis of microcarcinoma or technical advancements in detection methods and may also depend on environmental and genetic factors. However, the impacts and interactions of genetic and environmental factors remain controversial, and they may differ in Eastern and Western countries. The study’s purpose was to identify single nucleotide polymorphisms of genes related to cell differentiation and inflammation to influence thyroid cancer incidence and determine interactions with lifestyles in a large city hospital-based cohort. Genetic variants were selected by genome-wide association study with thyroid cancer participants (case; <i>n</i> = 495) and controls without cancers (<i>n</i> = 56,439). SNPs having gene–gene interactions were selected by generalized multifactor dimensionality reduction. Polygenic risk scores (PRSs) were generated by summing the number of selected SNP risk alleles. PRSs of the best model included 6 SNPs, that is, <i>DIRC3</i>_rs6759952, <i>GAP43</i>_rs13059137, <i>NRG1</i>_rs7834206, <i>PROM1</i>_rs72616195, <i>LRP1B</i>_rs1369535, and <i>LOC100507065</i>_rs11175834. Participants with a high-PRS had a higher thyroid cancer risk by 3.9-fold than those with a low-PRS. The following variables were related to an increased thyroid cancer risk; female (OR = 4.21), high white blood cell count (OR = 4.03), and high energy (OR = 7.00), low alcohol (OR = 4.11), and high seaweed (OR = 4.02) intakes. These variables also interacted with PRS to influence thyroid cancer risk. Meat/noodle diet patterns interacted with PRSs to increase thyroid cancer risk (<i>p</i> = 0.0023). In conclusion, women with a high-PRS associated with cell differentiation and inflammation were at an elevated thyroid cancer risk. Daily energy, seaweeds, and alcohol intake interacted with PRS for thyroid cancer risk. These results could be applied to personalized nutrition plans to reduce the risk of thyroid cancer.https://www.mdpi.com/2072-6694/13/7/1510gene–gene interactionthyroid cancerpolygenic risk scoresgenderwhite blood celldietary patterns |
| spellingShingle | Sang Shin Song ShaoKai Huang Sunmin Park Association of Polygenetic Risk Scores Related to Cell Differentiation and Inflammation with Thyroid Cancer Risk and Genetic Interaction with Dietary Intake Cancers gene–gene interaction thyroid cancer polygenic risk scores gender white blood cell dietary patterns |
| title | Association of Polygenetic Risk Scores Related to Cell Differentiation and Inflammation with Thyroid Cancer Risk and Genetic Interaction with Dietary Intake |
| title_full | Association of Polygenetic Risk Scores Related to Cell Differentiation and Inflammation with Thyroid Cancer Risk and Genetic Interaction with Dietary Intake |
| title_fullStr | Association of Polygenetic Risk Scores Related to Cell Differentiation and Inflammation with Thyroid Cancer Risk and Genetic Interaction with Dietary Intake |
| title_full_unstemmed | Association of Polygenetic Risk Scores Related to Cell Differentiation and Inflammation with Thyroid Cancer Risk and Genetic Interaction with Dietary Intake |
| title_short | Association of Polygenetic Risk Scores Related to Cell Differentiation and Inflammation with Thyroid Cancer Risk and Genetic Interaction with Dietary Intake |
| title_sort | association of polygenetic risk scores related to cell differentiation and inflammation with thyroid cancer risk and genetic interaction with dietary intake |
| topic | gene–gene interaction thyroid cancer polygenic risk scores gender white blood cell dietary patterns |
| url | https://www.mdpi.com/2072-6694/13/7/1510 |
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