Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation
Neutrophils are widely recognized to play an important role in acute inflammatory responses, and recent evidence has expanded their role to modulating chronic inflammatory and autoimmune diseases. Reactive oxygen species (ROS) and microbicidal compounds released from neutrophils that are recruited t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-07-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1660-3397/14/8/141 |
| _version_ | 1798034127995273216 |
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| author | Chun-Yu Chen Yung-Fong Tsai Wen-Yi Chang Shun-Chin Yang Tsong-Long Hwang |
| author_facet | Chun-Yu Chen Yung-Fong Tsai Wen-Yi Chang Shun-Chin Yang Tsong-Long Hwang |
| author_sort | Chun-Yu Chen |
| collection | DOAJ |
| description | Neutrophils are widely recognized to play an important role in acute inflammatory responses, and recent evidence has expanded their role to modulating chronic inflammatory and autoimmune diseases. Reactive oxygen species (ROS) and microbicidal compounds released from neutrophils that are recruited to the site of inflammation contribute to the pathogenesis of multiple inflammation-associated diseases such as chronic obstructive pulmonary disease, atherosclerosis, and hepatitis. Marine organisms are a valuable source of bioactive compounds with potential for industrial and pharmaceutical application. Marine natural products that inhibit neutrophil activation could be used as drugs for the treatment of inflammatory diseases. Numerous studies investigating marine natural products have reported novel anti-inflammatory agents. Nevertheless, the detailed mechanisms underlying their actions, which could facilitate our understanding of the molecular events occurring in neutrophils, have not been reported in most of the associated research studies. Therefore, in this review, we will present marine products that inhibit neutrophil-associated inflammation. Furthermore, we will be limiting the detailed discussion to agents with well-investigated molecular targets. |
| first_indexed | 2024-04-11T20:39:58Z |
| format | Article |
| id | doaj.art-88f30d8607d5494a8e14ebcac2186152 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T20:39:58Z |
| publishDate | 2016-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-88f30d8607d5494a8e14ebcac21861522022-12-22T04:04:14ZengMDPI AGMarine Drugs1660-33972016-07-0114814110.3390/md14080141md14080141Marine Natural Product Inhibitors of Neutrophil-Associated InflammationChun-Yu Chen0Yung-Fong Tsai1Wen-Yi Chang2Shun-Chin Yang3Tsong-Long Hwang4Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGraduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGraduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGraduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanGraduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanNeutrophils are widely recognized to play an important role in acute inflammatory responses, and recent evidence has expanded their role to modulating chronic inflammatory and autoimmune diseases. Reactive oxygen species (ROS) and microbicidal compounds released from neutrophils that are recruited to the site of inflammation contribute to the pathogenesis of multiple inflammation-associated diseases such as chronic obstructive pulmonary disease, atherosclerosis, and hepatitis. Marine organisms are a valuable source of bioactive compounds with potential for industrial and pharmaceutical application. Marine natural products that inhibit neutrophil activation could be used as drugs for the treatment of inflammatory diseases. Numerous studies investigating marine natural products have reported novel anti-inflammatory agents. Nevertheless, the detailed mechanisms underlying their actions, which could facilitate our understanding of the molecular events occurring in neutrophils, have not been reported in most of the associated research studies. Therefore, in this review, we will present marine products that inhibit neutrophil-associated inflammation. Furthermore, we will be limiting the detailed discussion to agents with well-investigated molecular targets.http://www.mdpi.com/1660-3397/14/8/141marine natural productsneutrophilsanti-inflammatoryreactive oxygen speciesformyl peptide receptorphospholipase |
| spellingShingle | Chun-Yu Chen Yung-Fong Tsai Wen-Yi Chang Shun-Chin Yang Tsong-Long Hwang Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation Marine Drugs marine natural products neutrophils anti-inflammatory reactive oxygen species formyl peptide receptor phospholipase |
| title | Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation |
| title_full | Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation |
| title_fullStr | Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation |
| title_full_unstemmed | Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation |
| title_short | Marine Natural Product Inhibitors of Neutrophil-Associated Inflammation |
| title_sort | marine natural product inhibitors of neutrophil associated inflammation |
| topic | marine natural products neutrophils anti-inflammatory reactive oxygen species formyl peptide receptor phospholipase |
| url | http://www.mdpi.com/1660-3397/14/8/141 |
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