Rational pharmacotherapy in modern gastroenterology
Abstract Introduction. Modern gastroenterology is characterized by the combined (comorbid) nature of the diseases. In treatment, this promotes polypharmacy and increases complications (drug lesions, allergic reactions, exacerbation of diseases of other organs and systems), and, importantly, increase...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2021-10-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/6411 |
| _version_ | 1797842181201854464 |
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| author | O. N. Minushkin |
| author_facet | O. N. Minushkin |
| author_sort | O. N. Minushkin |
| collection | DOAJ |
| description | Abstract Introduction. Modern gastroenterology is characterized by the combined (comorbid) nature of the diseases. In treatment, this promotes polypharmacy and increases complications (drug lesions, allergic reactions, exacerbation of diseases of other organs and systems), and, importantly, increases the cost of pharmacotherapy.Aim. To compare two pharmacotherapy options for patients with gallstone disease at the stage of biliary sludge and patients with biliary sludge combined with irritable bowel syndrome.Materials and methods. In the work, based on the experience of treating 170 patients, two options for pharmacotherapy are considered, which may well turn out to be rational in all respects. Option 1 - monotherapy aimed at one of the components that form a complex pathogenetic symptom complex. The basis for offering this treatment option is the biological concept of the “regulatory cascade”. Option 2 – “stepwise” (stepwise) therapy with the choice of the “base” drug for the first step. Evaluation of the effectiveness and rational correction for the second step of treatment and subsequent ones – if necessary. Results. The biliary sludge was eliminated or reduced in patients who received the UDCA monotherapy against the background of recovery of gastrointestinal motility. The overall treatment effect (for each nosology) in patients with biliary sludge and irritable bowel syndrome using the complex therapy (UDCA and mebeverin) was 84 and 87.8% respectively.Conclusions. Both options are rational today: 1st requires further study; 2nd – active use. Both options exclude polypharmacy and other adverse effects. |
| first_indexed | 2024-04-09T16:43:39Z |
| format | Article |
| id | doaj.art-88f4ab3d18e840e280d1c1aa8f09a7ff |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:43:39Z |
| publishDate | 2021-10-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-88f4ab3d18e840e280d1c1aa8f09a7ff2023-04-23T06:56:35ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902021-10-01015131810.21518/2079-701X-2021-15-13-185782Rational pharmacotherapy in modern gastroenterologyO. N. Minushkin0Central State Medical Academy of the Presidential Administration of the Russian FederationAbstract Introduction. Modern gastroenterology is characterized by the combined (comorbid) nature of the diseases. In treatment, this promotes polypharmacy and increases complications (drug lesions, allergic reactions, exacerbation of diseases of other organs and systems), and, importantly, increases the cost of pharmacotherapy.Aim. To compare two pharmacotherapy options for patients with gallstone disease at the stage of biliary sludge and patients with biliary sludge combined with irritable bowel syndrome.Materials and methods. In the work, based on the experience of treating 170 patients, two options for pharmacotherapy are considered, which may well turn out to be rational in all respects. Option 1 - monotherapy aimed at one of the components that form a complex pathogenetic symptom complex. The basis for offering this treatment option is the biological concept of the “regulatory cascade”. Option 2 – “stepwise” (stepwise) therapy with the choice of the “base” drug for the first step. Evaluation of the effectiveness and rational correction for the second step of treatment and subsequent ones – if necessary. Results. The biliary sludge was eliminated or reduced in patients who received the UDCA monotherapy against the background of recovery of gastrointestinal motility. The overall treatment effect (for each nosology) in patients with biliary sludge and irritable bowel syndrome using the complex therapy (UDCA and mebeverin) was 84 and 87.8% respectively.Conclusions. Both options are rational today: 1st requires further study; 2nd – active use. Both options exclude polypharmacy and other adverse effects.https://www.med-sovet.pro/jour/article/view/6411gastroenterologybiliary sludgeirritable bowel syndromecomorbid pathologyregulatory cascadetreatment |
| spellingShingle | O. N. Minushkin Rational pharmacotherapy in modern gastroenterology Медицинский совет gastroenterology biliary sludge irritable bowel syndrome comorbid pathology regulatory cascade treatment |
| title | Rational pharmacotherapy in modern gastroenterology |
| title_full | Rational pharmacotherapy in modern gastroenterology |
| title_fullStr | Rational pharmacotherapy in modern gastroenterology |
| title_full_unstemmed | Rational pharmacotherapy in modern gastroenterology |
| title_short | Rational pharmacotherapy in modern gastroenterology |
| title_sort | rational pharmacotherapy in modern gastroenterology |
| topic | gastroenterology biliary sludge irritable bowel syndrome comorbid pathology regulatory cascade treatment |
| url | https://www.med-sovet.pro/jour/article/view/6411 |
| work_keys_str_mv | AT onminushkin rationalpharmacotherapyinmoderngastroenterology |