A genetic mouse model of lean-NAFLD unveils sexual dimorphism in the liver-heart axis

A genetic mouse model of lean-NAFLD unveils sexual dimorphism in the liver-heart axis

Abstract Lean patients with NAFLD may develop cardiac complications independently of pre-existent metabolic disruptions and comorbidities. To address the underlying mechanisms independent of the development of obesity, we used a murine model of hepatic mitochondrial deficiency. The liver-heart axis...

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Bibliographic Details
Main Authors: Charlotte Burelle, Valentin Clapatiuc, Sonia Deschênes, Alexanne Cuillerier, Marine De Loof, Marie-Ève Higgins, Hugues Boël, Caroline Daneault, Billie Chouinard, Marie-Élaine Clavet, Nolwenn Tessier, Isabelle Croteau, Geneviève Chabot, Catherine Martel, Martin G. Sirois, Sylvie Lesage, Yan Burelle, Matthieu Ruiz
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06035-6

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