CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors

CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors

<p>Abstract</p> <p>Background</p> <p>DNA repair deficient tumor cells have been shown to accumulate high levels of DNA damage. Consequently, these cells become hyper-dependent on DNA damage response pathways, including the CHK1-kinase-mediated response. These observatio...

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Bibliographic Details
Main Authors: Look A Thomas, Sidi Samuel, Kennedy Richard D, Chen Clark C, D'Andrea Alan
Format: Article
Language:English
Published: BMC 2009-04-01
Series:Molecular Cancer
Online Access:http://www.molecular-cancer.com/content/8/1/24

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