Differences in systemic inflammation between cigarette and biomass smoke-induced COPD
Rafael Golpe,1 Irene Martín-Robles,1 Pilar Sanjuán-López,1 Luis Pérez-de-Llano,1 Carlos González-Juanatey,2 José L López-Campos,3,4 Elena Arellano-Orden4 1Respiratory Medicine Service, 2Cardiology Service, University Hospi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2017-09-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/differences-in-systemic-inflammation-between-cigarette-and-biomass-smo-peer-reviewed-article-COPD |
| _version_ | 1831789419195006976 |
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| author | Golpe R Martín-Robles I Sanjuán-López P Pérez-de-Llano L González-Juanatey C López-Campos JL Arellano-Orden E |
| author_facet | Golpe R Martín-Robles I Sanjuán-López P Pérez-de-Llano L González-Juanatey C López-Campos JL Arellano-Orden E |
| author_sort | Golpe R |
| collection | DOAJ |
| description | Rafael Golpe,1 Irene Martín-Robles,1 Pilar Sanjuán-López,1 Luis Pérez-de-Llano,1 Carlos González-Juanatey,2 José L López-Campos,3,4 Elena Arellano-Orden4 1Respiratory Medicine Service, 2Cardiology Service, University Hospital Lucus Augusti, Lugo, 3Medical-Surgical Unit of Respiratory Diseases, University Hospital Virgen del Rocío, Sevilla, 4Center for Biomedical Research in Respiratory Diseases Network, Carlos III Health Institute, Madrid, Spain Background and objective: It is known that biomarkers of systemic inflammation are raised in COPD caused by tobacco (T-COPD) compared with healthy controls, but there is less information on the inflammatory status of subjects with COPD caused by biomass smoke (B-COPD). In addition, the possible (if any) differences in inflammation between both types of the disease are still not well known. The aim of this study was to assess the inflammatory profile in B-COPD and T-COPD.Methods: A total of 20 subjects (15 men and five women) with T-COPD were matched one to one for sex, age and forced expiratory volume in 1 s (FEV1) to 20 B-COPD patients. In all, 20 sex-matched healthy subjects with normal lung function without smoking history or biomass exposure were included as controls. The following biomarkers were measured: exhaled nitric oxide, serum IL-6, IL-8, IL-5, IL-13, periostin, surfactant protein-P, TNF-α, IgE, erythrocyte sedimentation rate, C-reactive protein and fibrinogen. Complete blood count was also obtained.Results: The age of the subjects was 70.2±7.9 years and FEV1% was 56.2%±14.6%. Most inflammatory biomarkers were higher in both types of COPD than in healthy controls. IL-6, IL-8 and IL-5 were significantly higher in T-COPD than in B-COPD, without other significant differences.Conclusion: Both types of COPD are associated with high levels of systemic inflammation biomarkers. T-COPD patients have a higher systemic inflammatory status than the patients with B-COPD. Keywords: biomass smoke, COPD, cytokines, inflammation, smoking |
| first_indexed | 2024-12-22T14:09:14Z |
| format | Article |
| id | doaj.art-88f62dce3e324c5899b101a6faba6834 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-22T14:09:14Z |
| publishDate | 2017-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-88f62dce3e324c5899b101a6faba68342022-12-21T18:23:14ZengDove Medical PressInternational Journal of COPD1178-20052017-09-01Volume 122639264634542Differences in systemic inflammation between cigarette and biomass smoke-induced COPDGolpe RMartín-Robles ISanjuán-López PPérez-de-Llano LGonzález-Juanatey CLópez-Campos JLArellano-Orden ERafael Golpe,1 Irene Martín-Robles,1 Pilar Sanjuán-López,1 Luis Pérez-de-Llano,1 Carlos González-Juanatey,2 José L López-Campos,3,4 Elena Arellano-Orden4 1Respiratory Medicine Service, 2Cardiology Service, University Hospital Lucus Augusti, Lugo, 3Medical-Surgical Unit of Respiratory Diseases, University Hospital Virgen del Rocío, Sevilla, 4Center for Biomedical Research in Respiratory Diseases Network, Carlos III Health Institute, Madrid, Spain Background and objective: It is known that biomarkers of systemic inflammation are raised in COPD caused by tobacco (T-COPD) compared with healthy controls, but there is less information on the inflammatory status of subjects with COPD caused by biomass smoke (B-COPD). In addition, the possible (if any) differences in inflammation between both types of the disease are still not well known. The aim of this study was to assess the inflammatory profile in B-COPD and T-COPD.Methods: A total of 20 subjects (15 men and five women) with T-COPD were matched one to one for sex, age and forced expiratory volume in 1 s (FEV1) to 20 B-COPD patients. In all, 20 sex-matched healthy subjects with normal lung function without smoking history or biomass exposure were included as controls. The following biomarkers were measured: exhaled nitric oxide, serum IL-6, IL-8, IL-5, IL-13, periostin, surfactant protein-P, TNF-α, IgE, erythrocyte sedimentation rate, C-reactive protein and fibrinogen. Complete blood count was also obtained.Results: The age of the subjects was 70.2±7.9 years and FEV1% was 56.2%±14.6%. Most inflammatory biomarkers were higher in both types of COPD than in healthy controls. IL-6, IL-8 and IL-5 were significantly higher in T-COPD than in B-COPD, without other significant differences.Conclusion: Both types of COPD are associated with high levels of systemic inflammation biomarkers. T-COPD patients have a higher systemic inflammatory status than the patients with B-COPD. Keywords: biomass smoke, COPD, cytokines, inflammation, smokinghttps://www.dovepress.com/differences-in-systemic-inflammation-between-cigarette-and-biomass-smo-peer-reviewed-article-COPDBiomass SmokeChronic Obstructive Pulmonary DiseaseCytokinesInflammationSmoking. |
| spellingShingle | Golpe R Martín-Robles I Sanjuán-López P Pérez-de-Llano L González-Juanatey C López-Campos JL Arellano-Orden E Differences in systemic inflammation between cigarette and biomass smoke-induced COPD International Journal of COPD Biomass Smoke Chronic Obstructive Pulmonary Disease Cytokines Inflammation Smoking. |
| title | Differences in systemic inflammation between cigarette and biomass smoke-induced COPD |
| title_full | Differences in systemic inflammation between cigarette and biomass smoke-induced COPD |
| title_fullStr | Differences in systemic inflammation between cigarette and biomass smoke-induced COPD |
| title_full_unstemmed | Differences in systemic inflammation between cigarette and biomass smoke-induced COPD |
| title_short | Differences in systemic inflammation between cigarette and biomass smoke-induced COPD |
| title_sort | differences in systemic inflammation between cigarette and biomass smoke induced copd |
| topic | Biomass Smoke Chronic Obstructive Pulmonary Disease Cytokines Inflammation Smoking. |
| url | https://www.dovepress.com/differences-in-systemic-inflammation-between-cigarette-and-biomass-smo-peer-reviewed-article-COPD |
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