Microglia and astrocyte dysfunction in parkinson's disease
While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S096999612030303X |
| _version_ | 1818675923719815168 |
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| author | Tae-In Kam Jared T. Hinkle Ted M. Dawson Valina L. Dawson |
| author_facet | Tae-In Kam Jared T. Hinkle Ted M. Dawson Valina L. Dawson |
| author_sort | Tae-In Kam |
| collection | DOAJ |
| description | While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD. |
| first_indexed | 2024-12-17T08:35:18Z |
| format | Article |
| id | doaj.art-88f64456b6414592b5aec47fa35d49e9 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T08:35:18Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-88f64456b6414592b5aec47fa35d49e92022-12-21T21:56:30ZengElsevierNeurobiology of Disease1095-953X2020-10-01144105028Microglia and astrocyte dysfunction in parkinson's diseaseTae-In Kam0Jared T. Hinkle1Ted M. Dawson2Valina L. Dawson3Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USASolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USANeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Corresponding authors.Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Corresponding authors.While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases, including Parkinson's disease (PD). Recent studies have identified that PD-associated genes are expressed in glial cells as well as neurons and have crucial roles in microglia and astrocytes. Here, we discuss the role of microglia and astrocytes dysfunction in relation to PD-linked mutations and their implications in PD pathogenesis. A better understanding of microglia and astrocyte functions in PD may provide insights into neurodegeneration and novel therapeutic approaches for PD.http://www.sciencedirect.com/science/article/pii/S096999612030303XMicrogliaAstrocyteGliaNeuroinflammationNeurodegenerationParkinson's disease |
| spellingShingle | Tae-In Kam Jared T. Hinkle Ted M. Dawson Valina L. Dawson Microglia and astrocyte dysfunction in parkinson's disease Neurobiology of Disease Microglia Astrocyte Glia Neuroinflammation Neurodegeneration Parkinson's disease |
| title | Microglia and astrocyte dysfunction in parkinson's disease |
| title_full | Microglia and astrocyte dysfunction in parkinson's disease |
| title_fullStr | Microglia and astrocyte dysfunction in parkinson's disease |
| title_full_unstemmed | Microglia and astrocyte dysfunction in parkinson's disease |
| title_short | Microglia and astrocyte dysfunction in parkinson's disease |
| title_sort | microglia and astrocyte dysfunction in parkinson s disease |
| topic | Microglia Astrocyte Glia Neuroinflammation Neurodegeneration Parkinson's disease |
| url | http://www.sciencedirect.com/science/article/pii/S096999612030303X |
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