PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints
Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2017-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00142-1 |
| _version_ | 1818841786860175360 |
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| author | Saw-See Hong Hubert Marotte Guillaume Courbon Gary S. Firestein Pierre Boulanger Pierre Miossec |
| author_facet | Saw-See Hong Hubert Marotte Guillaume Courbon Gary S. Firestein Pierre Boulanger Pierre Miossec |
| author_sort | Saw-See Hong |
| collection | DOAJ |
| description | Proliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model. |
| first_indexed | 2024-12-19T04:31:37Z |
| format | Article |
| id | doaj.art-88f69cca0bc14b8abdae60547d936af1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:31:37Z |
| publishDate | 2017-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-88f69cca0bc14b8abdae60547d936af12022-12-21T20:35:51ZengNature PortfolioNature Communications2041-17232017-07-018111210.1038/s41467-017-00142-1PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic jointsSaw-See Hong0Hubert Marotte1Guillaume Courbon2Gary S. Firestein3Pierre Boulanger4Pierre Miossec5University of LyonDepartment of Bone and Osteoarticular Biology INSERM U1059, University Jean Monnet University of LyonDepartment of Bone and Osteoarticular Biology INSERM U1059, University Jean Monnet University of LyonSchool of Medicine, Division of Rheumatology, Allergy and Immunology, University of California at San DiegoUniversity of LyonUniversity of LyonProliferation of synoviocytes contributes to joint damage in rheumatoid arthritis. Here the authors show that targeting of these cells by a vector, consisting of a baculovirus conjugated to an adenovirus carrying the pro-apoptotic gene PUMA, has therapeutic efficacy in a rat arthritis model.https://doi.org/10.1038/s41467-017-00142-1 |
| spellingShingle | Saw-See Hong Hubert Marotte Guillaume Courbon Gary S. Firestein Pierre Boulanger Pierre Miossec PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints Nature Communications |
| title | PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints |
| title_full | PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints |
| title_fullStr | PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints |
| title_full_unstemmed | PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints |
| title_short | PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints |
| title_sort | puma gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints |
| url | https://doi.org/10.1038/s41467-017-00142-1 |
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