Application of Array-based Comparative Genome Hybridization in Children with Developmental Delay or Mental Retardation
Children with developmental delay or mental retardation (DD/MR) are commonly en countered in child neurology clinics, and establishing an etiologic diagnosis is a challenge for child neurologists. Among the etiologies, chromosomal imbalance is one of the most important causes. However, many of these...
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| Format: | Article |
| Language: | English |
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Elsevier
2008-12-01
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| Series: | Pediatrics and Neonatology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957209600139 |
| _version_ | 1818016988763521024 |
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| author | Jao-Shwann Liang Keiko Shimojima Toshiyuki Yamamoto |
| author_facet | Jao-Shwann Liang Keiko Shimojima Toshiyuki Yamamoto |
| author_sort | Jao-Shwann Liang |
| collection | DOAJ |
| description | Children with developmental delay or mental retardation (DD/MR) are commonly en countered in child neurology clinics, and establishing an etiologic diagnosis is a challenge for child neurologists. Among the etiologies, chromosomal imbalance is one of the most important causes. However, many of these chromosomal imbalances are submicroscopic and cannot be detected by conventional cytogenetic methods. Microarray-based comparative genomic hybridization (array CGH) is considered to be superior in the investigation of chromosomal deletions or duplications in children with DD/MR, and has been demonstrated to improve the diagnostic detection rate for these small chromosomal abnormalities. Here, we review the recent studies of array CGH in the evaluation of patients with idiopathic DD/MR. |
| first_indexed | 2024-04-14T07:20:44Z |
| format | Article |
| id | doaj.art-88f7c9b72e3d4328bd5315682e4e3401 |
| institution | Directory Open Access Journal |
| issn | 1875-9572 |
| language | English |
| last_indexed | 2024-04-14T07:20:44Z |
| publishDate | 2008-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj.art-88f7c9b72e3d4328bd5315682e4e34012022-12-22T02:06:10ZengElsevierPediatrics and Neonatology1875-95722008-12-0149621321710.1016/S1875-9572(09)60013-9Application of Array-based Comparative Genome Hybridization in Children with Developmental Delay or Mental RetardationJao-Shwann Liang0Keiko Shimojima1Toshiyuki Yamamoto2International Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women's Medical University, TaiwanInternational Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women's Medical University, TaiwanInternational Research and Educational Institute for Integrated Medical Sciences (IREIIMS), Tokyo Women's Medical University, TaiwanChildren with developmental delay or mental retardation (DD/MR) are commonly en countered in child neurology clinics, and establishing an etiologic diagnosis is a challenge for child neurologists. Among the etiologies, chromosomal imbalance is one of the most important causes. However, many of these chromosomal imbalances are submicroscopic and cannot be detected by conventional cytogenetic methods. Microarray-based comparative genomic hybridization (array CGH) is considered to be superior in the investigation of chromosomal deletions or duplications in children with DD/MR, and has been demonstrated to improve the diagnostic detection rate for these small chromosomal abnormalities. Here, we review the recent studies of array CGH in the evaluation of patients with idiopathic DD/MR.http://www.sciencedirect.com/science/article/pii/S1875957209600139array-based comparative genomic hybridizationcytogenic testdevelopmental delaymental retardation |
| spellingShingle | Jao-Shwann Liang Keiko Shimojima Toshiyuki Yamamoto Application of Array-based Comparative Genome Hybridization in Children with Developmental Delay or Mental Retardation Pediatrics and Neonatology array-based comparative genomic hybridization cytogenic test developmental delay mental retardation |
| title | Application of Array-based Comparative Genome Hybridization in Children with Developmental Delay or Mental Retardation |
| title_full | Application of Array-based Comparative Genome Hybridization in Children with Developmental Delay or Mental Retardation |
| title_fullStr | Application of Array-based Comparative Genome Hybridization in Children with Developmental Delay or Mental Retardation |
| title_full_unstemmed | Application of Array-based Comparative Genome Hybridization in Children with Developmental Delay or Mental Retardation |
| title_short | Application of Array-based Comparative Genome Hybridization in Children with Developmental Delay or Mental Retardation |
| title_sort | application of array based comparative genome hybridization in children with developmental delay or mental retardation |
| topic | array-based comparative genomic hybridization cytogenic test developmental delay mental retardation |
| url | http://www.sciencedirect.com/science/article/pii/S1875957209600139 |
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