A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply

A phenomenological model of proton FLASH oxygen depletion effects depending on tissue vasculature and oxygen supply

IntroductionRadiation-induced oxygen depletion in tissue is assumed as a contributor to the FLASH sparing effects. In this study, we simulated the heterogeneous oxygen depletion in the tissue surrounding the vessels and calculated the proton FLASH effective-dose-modifying factor (FEDMF), which could...

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Bibliographic Details
Main Authors: Wei Zou, Haram Kim, Eric S. Diffenderfer, David J. Carlson, Cameron J. Koch, Ying Xiao, BoonKeng K. Teo, Michele M. Kim, James M. Metz, Yi Fan, Amit Maity, Costas Koumenis, Theresa M. Busch, Rodney Wiersma, Keith A. Cengel, Lei Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
FLASH effect
oxygen depletion
proton
vasculature
hypoxic reduction factor
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1004121/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1004121/full

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