Cardiovascular disease-linked plasma proteins are mainly associated with lung volume
Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2023-03-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/9/2/00321-2022.full |
| _version_ | 1797809376188170240 |
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| author | Andreas Rydell Elisabet Nerpin XingWu Zhou Lars Lind Eva Lindberg Jenny Theorell Haglöw Tove Fall Christer Janson Karin Lisspers Sölve Elmståhl Suneela Zaigham Olle Melander Peter M. Nilsson Johan Ärnlöv Andrei Malinovschi |
| author_facet | Andreas Rydell Elisabet Nerpin XingWu Zhou Lars Lind Eva Lindberg Jenny Theorell Haglöw Tove Fall Christer Janson Karin Lisspers Sölve Elmståhl Suneela Zaigham Olle Melander Peter M. Nilsson Johan Ärnlöv Andrei Malinovschi |
| author_sort | Andreas Rydell |
| collection | DOAJ |
| description | Background
Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio.
Methods
We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV1, FVC (both % predicted) and FEV1/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort.
Results
Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV1/FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity.
Conclusions
Five proteins were associated with both FEV1 and FVC. Four proteins associated with only FVC and none with FEV1/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings. |
| first_indexed | 2024-03-13T06:51:42Z |
| format | Article |
| id | doaj.art-88f8945323e640219776faa489b28917 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-03-13T06:51:42Z |
| publishDate | 2023-03-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-88f8945323e640219776faa489b289172023-06-07T13:31:07ZengEuropean Respiratory SocietyERJ Open Research2312-05412023-03-019210.1183/23120541.00321-202200321-2022Cardiovascular disease-linked plasma proteins are mainly associated with lung volumeAndreas Rydell0Elisabet Nerpin1XingWu Zhou2Lars Lind3Eva Lindberg4Jenny Theorell Haglöw5Tove Fall6Christer Janson7Karin Lisspers8Sölve Elmståhl9Suneela Zaigham10Olle Melander11Peter M. Nilsson12Johan Ärnlöv13Andrei Malinovschi14 Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institute, Huddinge, Sweden Department of Medical Sciences, Uppsala University, Uppsala, Sweden Department of Medical Sciences, Uppsala University, Uppsala, Sweden Department of Medical Sciences, Uppsala University, Uppsala, Sweden Department of Medical Sciences, Uppsala University, Uppsala, Sweden Department of Medical Sciences, Uppsala University, Uppsala, Sweden Department of Medical Sciences, Uppsala University, Uppsala, Sweden Department of Medical Sciences, Uppsala University, Uppsala, Sweden Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden Department of Clinical Sciences, Lund University, Malmö, Sweden Department of Medical Sciences, Uppsala University, Uppsala, Sweden Department of Clinical Sciences, Lund University, Malmö, Sweden Department of Clinical Sciences, Lund University, Malmö, Sweden Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society (NVS), Karolinska Institute, Huddinge, Sweden Department of Medical Sciences, Uppsala University, Uppsala, Sweden Background Epidemiological studies have shown that impaired lung function is common and associated with increased risk of cardiovascular disease. Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. The aim was to study the association between plasma proteomics and forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC ratio. Methods We used a discovery and replication approach in two community-based cohorts, EpiHealth and the Malmö Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease- and metabolism-linked proteins in relation to FEV1, FVC (both % predicted) and FEV1/FVC ratio. A false discovery rate of 5% was used as the significance threshold in the discovery cohort. Results Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. No proteins were associated with FEV1/FVC ratio. A sensitivity analysis in EpiHealth revealed only minor changes after excluding individuals with known cardiovascular disease, diabetes or obesity. Conclusions Five proteins were associated with both FEV1 and FVC. Four proteins associated with only FVC and none with FEV1/FVC ratio, suggesting associations mainly through lung volume, not airway obstruction. However, additional studies are needed to investigate underlying mechanisms for these findings.http://openres.ersjournals.com/content/9/2/00321-2022.full |
| spellingShingle | Andreas Rydell Elisabet Nerpin XingWu Zhou Lars Lind Eva Lindberg Jenny Theorell Haglöw Tove Fall Christer Janson Karin Lisspers Sölve Elmståhl Suneela Zaigham Olle Melander Peter M. Nilsson Johan Ärnlöv Andrei Malinovschi Cardiovascular disease-linked plasma proteins are mainly associated with lung volume ERJ Open Research |
| title | Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
| title_full | Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
| title_fullStr | Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
| title_full_unstemmed | Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
| title_short | Cardiovascular disease-linked plasma proteins are mainly associated with lung volume |
| title_sort | cardiovascular disease linked plasma proteins are mainly associated with lung volume |
| url | http://openres.ersjournals.com/content/9/2/00321-2022.full |
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