MicroRNA-1-Mediated Inhibition of Cardiac Fibroblast Proliferation Through Targeting Cyclin D2 and CDK6

MicroRNA-1-Mediated Inhibition of Cardiac Fibroblast Proliferation Through Targeting Cyclin D2 and CDK6

MicroRNA-1 (miRNA-1) has been long viewed as a muscle-specific miRNA and plays a critical role in myocardium and cardiomyocytes by controlling myocyte growth and rhythm. We identified that miRNA-1 is expressed in cardiac fibroblasts, which are one of the major non-muscle cell types in myocardium and...

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Bibliographic Details
Main Authors: Nedyalka Valkov, Michelle E. King, Jacob Moeller, Hong Liu, Xiaofei Li, Peng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
cardiac fibroblasts
microRNA-1
cell proliferation
cell cycle regulator
cyclin D2
Cdk6
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2019.00065/full

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