Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder
Extracellular vesicles (EVs) are lipid bilayer-delimited particles released by cells, which play an essential role in intercellular communication by delivering cellular components including DNA, RNA, lipids, metabolites, cytoplasm, and cell surface proteins into recipient cells. EVs play a vital rol...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.843412/full |
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| author | Qian Wu Qian Wu Wen-Zhen Duan Wen-Zhen Duan Wen-Zhen Duan Jian-Bei Chen Xiao-Peng Zhao Xiao-Juan Li Yue-Yun Liu Qing-Yu Ma Zhe Xue Jia-Xu Chen Jia-Xu Chen |
| author_facet | Qian Wu Qian Wu Wen-Zhen Duan Wen-Zhen Duan Wen-Zhen Duan Jian-Bei Chen Xiao-Peng Zhao Xiao-Juan Li Yue-Yun Liu Qing-Yu Ma Zhe Xue Jia-Xu Chen Jia-Xu Chen |
| author_sort | Qian Wu |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are lipid bilayer-delimited particles released by cells, which play an essential role in intercellular communication by delivering cellular components including DNA, RNA, lipids, metabolites, cytoplasm, and cell surface proteins into recipient cells. EVs play a vital role in the pathogenesis of depression by transporting miRNA and effector molecules such as BDNF, IL34. Considering that some herbal therapies exhibit antidepressant effects, EVs might be a practical delivery approach for herbal medicine. Since EVs can cross the blood-brain barrier (BBB), one of the advantages of EV-mediated herbal drug delivery for treating depression with Chinese herbal medicine (CHM) is that EVs can transfer herbal medicine into the brain cells. This review focuses on discussing the roles of EVs in the pathophysiology of depression and outlines the emerging application of EVs in delivering CHM for the treatment of depression. |
| first_indexed | 2024-04-12T22:23:02Z |
| format | Article |
| id | doaj.art-88fa0140f536429eb5feb71987021c3b |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-12T22:23:02Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-88fa0140f536429eb5feb71987021c3b2022-12-22T03:14:17ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-03-011310.3389/fphar.2022.843412843412Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive DisorderQian Wu0Qian Wu1Wen-Zhen Duan2Wen-Zhen Duan3Wen-Zhen Duan4Jian-Bei Chen5Xiao-Peng Zhao6Xiao-Juan Li7Yue-Yun Liu8Qing-Yu Ma9Zhe Xue10Jia-Xu Chen11Jia-Xu Chen12School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesDivision of Neurobiology, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesThe Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesProgram in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United StatesSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaGuangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Jinan University, Guangzhou, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaGuangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Jinan University, Guangzhou, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaGuangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Jinan University, Guangzhou, ChinaExtracellular vesicles (EVs) are lipid bilayer-delimited particles released by cells, which play an essential role in intercellular communication by delivering cellular components including DNA, RNA, lipids, metabolites, cytoplasm, and cell surface proteins into recipient cells. EVs play a vital role in the pathogenesis of depression by transporting miRNA and effector molecules such as BDNF, IL34. Considering that some herbal therapies exhibit antidepressant effects, EVs might be a practical delivery approach for herbal medicine. Since EVs can cross the blood-brain barrier (BBB), one of the advantages of EV-mediated herbal drug delivery for treating depression with Chinese herbal medicine (CHM) is that EVs can transfer herbal medicine into the brain cells. This review focuses on discussing the roles of EVs in the pathophysiology of depression and outlines the emerging application of EVs in delivering CHM for the treatment of depression.https://www.frontiersin.org/articles/10.3389/fphar.2022.843412/fullphytochemialsherbal therapiesextracellular vehiclesexosomesectosomesmicrovescicles |
| spellingShingle | Qian Wu Qian Wu Wen-Zhen Duan Wen-Zhen Duan Wen-Zhen Duan Jian-Bei Chen Xiao-Peng Zhao Xiao-Juan Li Yue-Yun Liu Qing-Yu Ma Zhe Xue Jia-Xu Chen Jia-Xu Chen Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder Frontiers in Pharmacology phytochemials herbal therapies extracellular vehicles exosomes ectosomes microvescicles |
| title | Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder |
| title_full | Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder |
| title_fullStr | Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder |
| title_full_unstemmed | Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder |
| title_short | Extracellular Vesicles: Emerging Roles in Developing Therapeutic Approach and Delivery Tool of Chinese Herbal Medicine for the Treatment of Depressive Disorder |
| title_sort | extracellular vesicles emerging roles in developing therapeutic approach and delivery tool of chinese herbal medicine for the treatment of depressive disorder |
| topic | phytochemials herbal therapies extracellular vehicles exosomes ectosomes microvescicles |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.843412/full |
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