Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution
Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory dermatological condition characterized by painful and recurrent nodules and purulent abscesses. HS can have a devastating impact on the quality of life of patients. This condition is commonly localized to the axilla, groin, pe...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-03-01
|
| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/13/3/268 |
| _version_ | 1797242287748546560 |
|---|---|
| author | Faith D. Huynh Giovanni Damiani Christopher G. Bunick |
| author_facet | Faith D. Huynh Giovanni Damiani Christopher G. Bunick |
| author_sort | Faith D. Huynh |
| collection | DOAJ |
| description | Hidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory dermatological condition characterized by painful and recurrent nodules and purulent abscesses. HS can have a devastating impact on the quality of life of patients. This condition is commonly localized to the axilla, groin, perineal, and inframammary regions, and can develop fistulas and sinus tracts over time. Its pathogenesis remains elusive and is best characterized at the moment as multi-factorial. Additionally, questions remain about the role of cutaneous dysbiosis as a primary HS trigger or as a secondary perturbation due to HS inflammation. This article features works in relation to HS and its interplay with bacterial microflora. We address current treatment approaches and their impact on HS-related bacteria, as well as areas of therapeutic innovation. In the future, disease-modifying or remittive therapy will likely combine an advanced/targeted anti-inflammatory approach with one that effectively modulates cutaneous and deep tissue dysbiosis. |
| first_indexed | 2024-04-24T18:36:50Z |
| format | Article |
| id | doaj.art-88fca98ace764e1f8b51d213eb582826 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-04-24T18:36:50Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-88fca98ace764e1f8b51d213eb5828262024-03-27T13:18:14ZengMDPI AGAntibiotics2079-63822024-03-0113326810.3390/antibiotics13030268Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment EvolutionFaith D. Huynh0Giovanni Damiani1Christopher G. Bunick2Yale School of Medicine, New Haven, CT 06510, USADepartment of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, ItalyDepartment of Dermatology and Program in Translational Biomedicine, Yale School of Medicine, New Haven, CT 06520, USAHidradenitis suppurativa (HS), or acne inversa, is a chronic inflammatory dermatological condition characterized by painful and recurrent nodules and purulent abscesses. HS can have a devastating impact on the quality of life of patients. This condition is commonly localized to the axilla, groin, perineal, and inframammary regions, and can develop fistulas and sinus tracts over time. Its pathogenesis remains elusive and is best characterized at the moment as multi-factorial. Additionally, questions remain about the role of cutaneous dysbiosis as a primary HS trigger or as a secondary perturbation due to HS inflammation. This article features works in relation to HS and its interplay with bacterial microflora. We address current treatment approaches and their impact on HS-related bacteria, as well as areas of therapeutic innovation. In the future, disease-modifying or remittive therapy will likely combine an advanced/targeted anti-inflammatory approach with one that effectively modulates cutaneous and deep tissue dysbiosis.https://www.mdpi.com/2079-6382/13/3/268acne inversabiofilm formationanaerobesantibioticsbacteriaresistance |
| spellingShingle | Faith D. Huynh Giovanni Damiani Christopher G. Bunick Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution Antibiotics acne inversa biofilm formation anaerobes antibiotics bacteria resistance |
| title | Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution |
| title_full | Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution |
| title_fullStr | Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution |
| title_full_unstemmed | Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution |
| title_short | Rethinking Hidradenitis Suppurativa Management: Insights into Bacterial Interactions and Treatment Evolution |
| title_sort | rethinking hidradenitis suppurativa management insights into bacterial interactions and treatment evolution |
| topic | acne inversa biofilm formation anaerobes antibiotics bacteria resistance |
| url | https://www.mdpi.com/2079-6382/13/3/268 |
| work_keys_str_mv | AT faithdhuynh rethinkinghidradenitissuppurativamanagementinsightsintobacterialinteractionsandtreatmentevolution AT giovannidamiani rethinkinghidradenitissuppurativamanagementinsightsintobacterialinteractionsandtreatmentevolution AT christophergbunick rethinkinghidradenitissuppurativamanagementinsightsintobacterialinteractionsandtreatmentevolution |