Transcriptome-wide profiling discover: PM2.5 aggravates airway dysfunction through epithelial barrier damage regulated by Stanniocalcin 2 in an OVA-induced model

Transcriptome-wide profiling discover: PM2.5 aggravates airway dysfunction through epithelial barrier damage regulated by Stanniocalcin 2 in an OVA-induced model

Background: Epidemiologic evidence suggests that PM2.5 exposure aggravates asthma, but the molecular mechanisms are not fully discovered. Methods: Ovalbumin (OVA)-induced mice exposed to PM2.5 were constructed. Pathological staining and immunofluorescence were performed in in vivo study. Gene set en...

Full description

Bibliographic Details
Main Authors: Lei Zhang, Xiang He, Ying Xiong, Qin Ran, Anying Xiong, Junyi Wang, Dehong Wu, Bin Niu, Guoping Li
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Transcriptome
PM2.5
Asthma
STC2
Airway epithelial barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651321005200

Similar Items

Similar Items