The Meaning of Immune Reconstitution after Alemtuzumab Therapy in Multiple Sclerosis
Alemtuzumab is a monoclonal antibody that binds to CD52, a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes are derived. It is currently used as an immune reconstitution therapy in patients with relapsing–remitting multiple sclerosis. Alemt...
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MDPI AG
2020-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/6/1396 |
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| author | Simona Rolla Alessandro Maglione Stefania Federica De Mercanti Marinella Clerico |
| author_facet | Simona Rolla Alessandro Maglione Stefania Federica De Mercanti Marinella Clerico |
| author_sort | Simona Rolla |
| collection | DOAJ |
| description | Alemtuzumab is a monoclonal antibody that binds to CD52, a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes are derived. It is currently used as an immune reconstitution therapy in patients with relapsing–remitting multiple sclerosis. Alemtuzumab treatment is an intermittent infusion that induces long-term remission of Multiple Sclerosis also in the treatment-free period. After the robust T and B cell depletion induced by alemtuzumab, the immune system undergoes radical changes during its reconstitution. In this review, we will discuss the current knowledge on the reconstitution of the lymphocyte repertoire after alemtuzumab treatment and how it could affect the development of side effects, which led to its temporary suspension by the European Medical Agency. |
| first_indexed | 2024-03-10T19:22:59Z |
| format | Article |
| id | doaj.art-88feb81e51aa42c3abcc62a3bd274d48 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:22:59Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-88feb81e51aa42c3abcc62a3bd274d482023-11-20T02:47:11ZengMDPI AGCells2073-44092020-06-0196139610.3390/cells9061396The Meaning of Immune Reconstitution after Alemtuzumab Therapy in Multiple SclerosisSimona Rolla0Alessandro Maglione1Stefania Federica De Mercanti2Marinella Clerico3Department of Clinical and Biological Sciences, University of Turin, 10043 Orbassano (TO), ItalyDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano (TO), ItalyDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano (TO), ItalyDepartment of Clinical and Biological Sciences, University of Turin, 10043 Orbassano (TO), ItalyAlemtuzumab is a monoclonal antibody that binds to CD52, a protein present on the surface of mature lymphocytes, but not on the stem cells from which these lymphocytes are derived. It is currently used as an immune reconstitution therapy in patients with relapsing–remitting multiple sclerosis. Alemtuzumab treatment is an intermittent infusion that induces long-term remission of Multiple Sclerosis also in the treatment-free period. After the robust T and B cell depletion induced by alemtuzumab, the immune system undergoes radical changes during its reconstitution. In this review, we will discuss the current knowledge on the reconstitution of the lymphocyte repertoire after alemtuzumab treatment and how it could affect the development of side effects, which led to its temporary suspension by the European Medical Agency.https://www.mdpi.com/2073-4409/9/6/1396Alemtuzumabmultiple sclerosismode of actionimmune reconstitution |
| spellingShingle | Simona Rolla Alessandro Maglione Stefania Federica De Mercanti Marinella Clerico The Meaning of Immune Reconstitution after Alemtuzumab Therapy in Multiple Sclerosis Cells Alemtuzumab multiple sclerosis mode of action immune reconstitution |
| title | The Meaning of Immune Reconstitution after Alemtuzumab Therapy in Multiple Sclerosis |
| title_full | The Meaning of Immune Reconstitution after Alemtuzumab Therapy in Multiple Sclerosis |
| title_fullStr | The Meaning of Immune Reconstitution after Alemtuzumab Therapy in Multiple Sclerosis |
| title_full_unstemmed | The Meaning of Immune Reconstitution after Alemtuzumab Therapy in Multiple Sclerosis |
| title_short | The Meaning of Immune Reconstitution after Alemtuzumab Therapy in Multiple Sclerosis |
| title_sort | meaning of immune reconstitution after alemtuzumab therapy in multiple sclerosis |
| topic | Alemtuzumab multiple sclerosis mode of action immune reconstitution |
| url | https://www.mdpi.com/2073-4409/9/6/1396 |
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