Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature Review
We report on a clinical case of capecitabine-induced acute ileitis in a patient treated with pre-operative concurrent chemoradiation with capecitabine for locally advanced rectal cancer and provide a comprehensive literature review. This a rare, but life-threatening, clinical situation, that clinici...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/30/10/655 |
| _version_ | 1827721243861712896 |
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| author | Andrea Brignoli Eleonora Ferrara Micol Zannetti Gianfranco Loi Laura Forti Carlo Socci Alessandro Carriero Alessandra Gennari Marco Krengli Pierfrancesco Franco |
| author_facet | Andrea Brignoli Eleonora Ferrara Micol Zannetti Gianfranco Loi Laura Forti Carlo Socci Alessandro Carriero Alessandra Gennari Marco Krengli Pierfrancesco Franco |
| author_sort | Andrea Brignoli |
| collection | DOAJ |
| description | We report on a clinical case of capecitabine-induced acute ileitis in a patient treated with pre-operative concurrent chemoradiation with capecitabine for locally advanced rectal cancer and provide a comprehensive literature review. This a rare, but life-threatening, clinical situation, that clinicians should be aware of. Severe persistent diarrhea is the most frequent clinical feature and computed tomography is a valid tool for diagnosis. Conservative management includes capecitabine withdrawal, antidiarrheal therapy and endovenous hydration, together with dietary modifications and broad-spectrum antibiotics. Pelvic irradiation represents an adjunctive risk factor, which may increase the likelihood of occurrence of terminal ileitis. Early recognition and prompt intervention are crucial for successful clinical management. |
| first_indexed | 2024-03-10T21:19:49Z |
| format | Article |
| id | doaj.art-88ff37fd971c4fbe902b7d1749b81b1d |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-10T21:19:49Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-88ff37fd971c4fbe902b7d1749b81b1d2023-11-19T16:10:59ZengMDPI AGCurrent Oncology1198-00521718-77292023-10-0130109063907710.3390/curroncol30100655Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature ReviewAndrea Brignoli0Eleonora Ferrara1Micol Zannetti2Gianfranco Loi3Laura Forti4Carlo Socci5Alessandro Carriero6Alessandra Gennari7Marco Krengli8Pierfrancesco Franco9Division of Radiation Oncology, University Hospital “Maggiore della Carità”, 28100 Novara, ItalyDivision of Radiation Oncology, University Hospital “Maggiore della Carità”, 28100 Novara, ItalyDivision of Radiation Oncology, University Hospital “Maggiore della Carità”, 28100 Novara, ItalyDepartment of Medical Physics, University Hospital “Maggiore della Carità”, 28100 Novara, ItalyDivision of Medical Oncology, University Hospital “Maggiore della Carità”, 28100 Novara, ItalyDivision of Surgery, Hospital ‘S.S. Trinita’, 28021 Borgomanero, ItalyDepartment of Translational Medicine, University of the Eastern Piedmont, 28100 Novara, ItalyDepartment of Translational Medicine, University of the Eastern Piedmont, 28100 Novara, ItalyRadiation Oncology, Veneto Institute of Oncology IOV-IRCCS, 35100 Padua, ItalyDivision of Radiation Oncology, University Hospital “Maggiore della Carità”, 28100 Novara, ItalyWe report on a clinical case of capecitabine-induced acute ileitis in a patient treated with pre-operative concurrent chemoradiation with capecitabine for locally advanced rectal cancer and provide a comprehensive literature review. This a rare, but life-threatening, clinical situation, that clinicians should be aware of. Severe persistent diarrhea is the most frequent clinical feature and computed tomography is a valid tool for diagnosis. Conservative management includes capecitabine withdrawal, antidiarrheal therapy and endovenous hydration, together with dietary modifications and broad-spectrum antibiotics. Pelvic irradiation represents an adjunctive risk factor, which may increase the likelihood of occurrence of terminal ileitis. Early recognition and prompt intervention are crucial for successful clinical management.https://www.mdpi.com/1718-7729/30/10/655rectal cancerradiation therapyileitiscapecitabineconcurrent radiochemotherapy |
| spellingShingle | Andrea Brignoli Eleonora Ferrara Micol Zannetti Gianfranco Loi Laura Forti Carlo Socci Alessandro Carriero Alessandra Gennari Marco Krengli Pierfrancesco Franco Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature Review Current Oncology rectal cancer radiation therapy ileitis capecitabine concurrent radiochemotherapy |
| title | Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature Review |
| title_full | Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature Review |
| title_fullStr | Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature Review |
| title_full_unstemmed | Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature Review |
| title_short | Capecitabine-Induced Ileitis during Neoadjuvant Pelvic Radio-Chemotherapy for Locally Advanced Rectal Cancer: A Case Report with Literature Review |
| title_sort | capecitabine induced ileitis during neoadjuvant pelvic radio chemotherapy for locally advanced rectal cancer a case report with literature review |
| topic | rectal cancer radiation therapy ileitis capecitabine concurrent radiochemotherapy |
| url | https://www.mdpi.com/1718-7729/30/10/655 |
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