Synaptic clustering during development and learning: The why, when and how
In order to contribute to a functional network a neuron must make specific connections and integrate the synaptic inputs that it receives in a meaningful way. Previous modeling and experimental studies have predicted that this specificity could entail a subcellular organization whereby synapses that...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2012-05-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00070/full |
| _version_ | 1818156137596321792 |
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| author | Johan eWinnubst Christian eLohmann |
| author_facet | Johan eWinnubst Christian eLohmann |
| author_sort | Johan eWinnubst |
| collection | DOAJ |
| description | In order to contribute to a functional network a neuron must make specific connections and integrate the synaptic inputs that it receives in a meaningful way. Previous modeling and experimental studies have predicted that this specificity could entail a subcellular organization whereby synapses that carry similar information are clustered together on local stretches of dendrite. Recent imaging studies have observed exactly this kind of synaptic clustering during development and learning in different neuronal circuits. Interestingly, this organization is found to be dependent on synaptic activity through a mechanism that most likely involves local plasticity mechanisms. Here we discuss these new insights and give an overview of the candidate plasticity mechanism that could be involved. |
| first_indexed | 2024-12-11T14:53:31Z |
| format | Article |
| id | doaj.art-88ffae9c7b8a446088aa0020d066908d |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-12-11T14:53:31Z |
| publishDate | 2012-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-88ffae9c7b8a446088aa0020d066908d2022-12-22T01:01:22ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992012-05-01510.3389/fnmol.2012.0007025591Synaptic clustering during development and learning: The why, when and howJohan eWinnubst0Christian eLohmann1Netherlands Institute for NeuroscienceNetherlands Institute for NeuroscienceIn order to contribute to a functional network a neuron must make specific connections and integrate the synaptic inputs that it receives in a meaningful way. Previous modeling and experimental studies have predicted that this specificity could entail a subcellular organization whereby synapses that carry similar information are clustered together on local stretches of dendrite. Recent imaging studies have observed exactly this kind of synaptic clustering during development and learning in different neuronal circuits. Interestingly, this organization is found to be dependent on synaptic activity through a mechanism that most likely involves local plasticity mechanisms. Here we discuss these new insights and give an overview of the candidate plasticity mechanism that could be involved.http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00070/fullDendritessynaptic plasticitysynapse developmentdendritic integrationactivity-dependentspontaneous activity |
| spellingShingle | Johan eWinnubst Christian eLohmann Synaptic clustering during development and learning: The why, when and how Frontiers in Molecular Neuroscience Dendrites synaptic plasticity synapse development dendritic integration activity-dependent spontaneous activity |
| title | Synaptic clustering during development and learning: The why, when and how |
| title_full | Synaptic clustering during development and learning: The why, when and how |
| title_fullStr | Synaptic clustering during development and learning: The why, when and how |
| title_full_unstemmed | Synaptic clustering during development and learning: The why, when and how |
| title_short | Synaptic clustering during development and learning: The why, when and how |
| title_sort | synaptic clustering during development and learning the why when and how |
| topic | Dendrites synaptic plasticity synapse development dendritic integration activity-dependent spontaneous activity |
| url | http://journal.frontiersin.org/Journal/10.3389/fnmol.2012.00070/full |
| work_keys_str_mv | AT johanewinnubst synapticclusteringduringdevelopmentandlearningthewhywhenandhow AT christianelohmann synapticclusteringduringdevelopmentandlearningthewhywhenandhow |