The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodules
ABSTRACT Context: FNAC thyroid is more sensitive as well as specific in segregating neoplastic and non-neoplastic thyroid lesions. Identification of predominant cell pattern, cell morphology and background details in FNAC smears play an important role in categorisation of various thyroid lesion...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-02-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/2747/23-%205172_E(C)_PF1(M)_F(P)_PF1(P)_u.pdf |
| _version_ | 1818515011882975232 |
|---|---|
| author | Anshu Gupta Sonia Sharma Shivani Kalhan Atul Gupta Sharmila Dudani Amit Devra |
| author_facet | Anshu Gupta Sonia Sharma Shivani Kalhan Atul Gupta Sharmila Dudani Amit Devra |
| author_sort | Anshu Gupta |
| collection | DOAJ |
| description | ABSTRACT
Context: FNAC thyroid is more sensitive as well as specific in
segregating neoplastic and non-neoplastic thyroid lesions.
Identification of predominant cell pattern, cell morphology and
background details in FNAC smears play an important role in
categorisation of various thyroid lesions with accuracy. Marginal vacuoles (MVs) have been described as irregular cytoplasmic vacuoles with largely unstained central area. MVs, although suggestive of thyrotoxicosis, are non-specific, as they
are also encountered in non- toxic goitre, Hashimoto’s thyroiditis and follicular carcinoma. This cytologic finding therefore deserves further study to precisely delineate its utility.
Aims & Objective: To investigate whether MVs have a diagnostic role in FNAC of solitary thyroid nodule
Setting & Design: This study was conducted on 40 patients
who presented with solitary thyroid nodule.
Methods & Material: Forty patients having solitary thyroid
nodule were subjected to FNAC on an outpatient basis. Their
cytomorphological features were studied with special attention
to presence of MVs. MVs if present were then graded as no/
scant (gradeI ), moderate (gradeII) and abundant (gradeIII).
Results and Conclusion: Majority (77.5%) of nodular goitres
had insignificant MVs (gradeI) in their smears. Significant MVs
(gradeII+III) were limited to autoimmune thyroiditis presenting
as solitary nodule and follicular neoplasms. Abundant MVs/
gradeIII were seen in follicular neoplasm only. MVs were not
present in rest of neoplastic goitres. This implies that MVs are
a marker of follicular differentiation. |
| first_indexed | 2024-12-11T00:23:27Z |
| format | Article |
| id | doaj.art-89001d9d01af4af9aefc96b0c4f97e4b |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-11T00:23:27Z |
| publishDate | 2013-02-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-89001d9d01af4af9aefc96b0c4f97e4b2022-12-22T01:27:40ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-02-017228428610.7860/JCDR/2013/5172.2747The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodules Anshu Gupta0 Sonia Sharma1Shivani Kalhan2 Atul Gupta3Sharmila Dudani4Amit Devra5Associate Professor, Department of Pathology, Saraswathi Instt of Medical Sciences, Anwarpur, Hapur U.P., India. Assisstant Professor, Department of Pathology, Army College of Medical Sciences, Delhi Cantt, India.Professor, Department of Pathology, Saraswathi Instt of Medical Sciences, Anwarpur, Hapur, U.P., India.Professor & Head, Department of Pathology, S.N.M.C., Agra, U.P., India.Assistant Professor, Department of Pathology, Army College of Medical Sciences, Delhi Cantt. India.Consultant Urologist and Transplant Surgeon Pushpawati Singhania Research, Instt, Sheikh Sarai, New Delhi, India.ABSTRACT Context: FNAC thyroid is more sensitive as well as specific in segregating neoplastic and non-neoplastic thyroid lesions. Identification of predominant cell pattern, cell morphology and background details in FNAC smears play an important role in categorisation of various thyroid lesions with accuracy. Marginal vacuoles (MVs) have been described as irregular cytoplasmic vacuoles with largely unstained central area. MVs, although suggestive of thyrotoxicosis, are non-specific, as they are also encountered in non- toxic goitre, Hashimoto’s thyroiditis and follicular carcinoma. This cytologic finding therefore deserves further study to precisely delineate its utility. Aims & Objective: To investigate whether MVs have a diagnostic role in FNAC of solitary thyroid nodule Setting & Design: This study was conducted on 40 patients who presented with solitary thyroid nodule. Methods & Material: Forty patients having solitary thyroid nodule were subjected to FNAC on an outpatient basis. Their cytomorphological features were studied with special attention to presence of MVs. MVs if present were then graded as no/ scant (gradeI ), moderate (gradeII) and abundant (gradeIII). Results and Conclusion: Majority (77.5%) of nodular goitres had insignificant MVs (gradeI) in their smears. Significant MVs (gradeII+III) were limited to autoimmune thyroiditis presenting as solitary nodule and follicular neoplasms. Abundant MVs/ gradeIII were seen in follicular neoplasm only. MVs were not present in rest of neoplastic goitres. This implies that MVs are a marker of follicular differentiation.https://jcdr.net/articles/PDF/2747/23-%205172_E(C)_PF1(M)_F(P)_PF1(P)_u.pdfthyroidmarginal vacuolessolitary thyroid nodule |
| spellingShingle | Anshu Gupta Sonia Sharma Shivani Kalhan Atul Gupta Sharmila Dudani Amit Devra The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodules Journal of Clinical and Diagnostic Research thyroid marginal vacuoles solitary thyroid nodule |
| title | The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodules |
| title_full | The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodules |
| title_fullStr | The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodules |
| title_full_unstemmed | The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodules |
| title_short | The Diagnostic Role of the Marginal Vacuoles in FNAC of Solitary Thyroid Nodules |
| title_sort | diagnostic role of the marginal vacuoles in fnac of solitary thyroid nodules |
| topic | thyroid marginal vacuoles solitary thyroid nodule |
| url | https://jcdr.net/articles/PDF/2747/23-%205172_E(C)_PF1(M)_F(P)_PF1(P)_u.pdf |
| work_keys_str_mv | AT anshugupta thediagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT soniasharma thediagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT shivanikalhan thediagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT atulgupta thediagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT sharmiladudani thediagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT amitdevra thediagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT anshugupta diagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT soniasharma diagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT shivanikalhan diagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT atulgupta diagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT sharmiladudani diagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules AT amitdevra diagnosticroleofthemarginalvacuolesinfnacofsolitarythyroidnodules |