Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity
ABSTRACTDue to the annual increase in its production and consumption in occupational environments, the adverse blood outcomes caused by benzene are of concern. However, the mechanism of benzene-induced hematopoietic damage remains elusive. Here, we report that benzene exposure causes hematopoietic d...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2323227 |
| _version_ | 1827330680826101760 |
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| author | Lei Zhang Ziyan Liu Wei Zhang Jingyu Wang Huiwen Kang Jiaru Jing Lin Han Ai Gao |
| author_facet | Lei Zhang Ziyan Liu Wei Zhang Jingyu Wang Huiwen Kang Jiaru Jing Lin Han Ai Gao |
| author_sort | Lei Zhang |
| collection | DOAJ |
| description | ABSTRACTDue to the annual increase in its production and consumption in occupational environments, the adverse blood outcomes caused by benzene are of concern. However, the mechanism of benzene-induced hematopoietic damage remains elusive. Here, we report that benzene exposure causes hematopoietic damage in a dose-dependent manner and is associated with disturbances in gut microbiota-long chain fatty acids (LCFAs)-inflammation axis. C57BL/6J mice exposed to benzene for 45 days were found to have a significant reduction in whole blood cells and the suppression of hematopoiesis, an increase in Bacteroides acidifaciens and a decrease in Lactobacillus murinus. Recipient mice transplanted with fecal microbiota from benzene-exposed mice showed potential for hematopoietic disruption, LCFAs, and interleukin-5 (IL-5) elevation. Abnormally elevated plasma LCFAs, especially palmitoleic acid (POA) exacerbated benzene-induced immune-inflammation and hematopoietic damage via carnitine palmitoyltransferase 2 (CPT2)-mediated disorder of fatty acid oxidation. Notably, oral administration of probiotics protects the mice against benzene-induced hematopoietic toxicity. In summary, our data reveal that the gut microbiota-POA-IL-5 axis is engaged in benzene-induced hematopoietic damage. Probiotics might be a promising candidate to prevent hematopoietic abnormalities from benzene exposure. |
| first_indexed | 2024-03-07T16:17:59Z |
| format | Article |
| id | doaj.art-8900428ab64b4a9fbc0476055dc83349 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-03-07T16:17:59Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-8900428ab64b4a9fbc0476055dc833492024-03-04T10:25:14ZengTaylor & Francis GroupGut Microbes1949-09761949-09842024-12-0116110.1080/19490976.2024.2323227Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicityLei Zhang0Ziyan Liu1Wei Zhang2Jingyu Wang3Huiwen Kang4Jiaru Jing5Lin Han6Ai Gao7Department of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, ChinaDepartment of Occupational Health and Environmental Health, School of Public Health, Capital Medical University, Beijing, ChinaABSTRACTDue to the annual increase in its production and consumption in occupational environments, the adverse blood outcomes caused by benzene are of concern. However, the mechanism of benzene-induced hematopoietic damage remains elusive. Here, we report that benzene exposure causes hematopoietic damage in a dose-dependent manner and is associated with disturbances in gut microbiota-long chain fatty acids (LCFAs)-inflammation axis. C57BL/6J mice exposed to benzene for 45 days were found to have a significant reduction in whole blood cells and the suppression of hematopoiesis, an increase in Bacteroides acidifaciens and a decrease in Lactobacillus murinus. Recipient mice transplanted with fecal microbiota from benzene-exposed mice showed potential for hematopoietic disruption, LCFAs, and interleukin-5 (IL-5) elevation. Abnormally elevated plasma LCFAs, especially palmitoleic acid (POA) exacerbated benzene-induced immune-inflammation and hematopoietic damage via carnitine palmitoyltransferase 2 (CPT2)-mediated disorder of fatty acid oxidation. Notably, oral administration of probiotics protects the mice against benzene-induced hematopoietic toxicity. In summary, our data reveal that the gut microbiota-POA-IL-5 axis is engaged in benzene-induced hematopoietic damage. Probiotics might be a promising candidate to prevent hematopoietic abnormalities from benzene exposure.https://www.tandfonline.com/doi/10.1080/19490976.2024.2323227Benzenehematotoxicitygut microbiotalong-chain fatty acidsprobiotics |
| spellingShingle | Lei Zhang Ziyan Liu Wei Zhang Jingyu Wang Huiwen Kang Jiaru Jing Lin Han Ai Gao Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity Gut Microbes Benzene hematotoxicity gut microbiota long-chain fatty acids probiotics |
| title | Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity |
| title_full | Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity |
| title_fullStr | Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity |
| title_full_unstemmed | Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity |
| title_short | Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity |
| title_sort | gut microbiota palmitoleic acid interleukin 5 axis orchestrates benzene induced hematopoietic toxicity |
| topic | Benzene hematotoxicity gut microbiota long-chain fatty acids probiotics |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2323227 |
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