Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during Pregnancy
<b>Introduction:</b> This research aims to describe a progressive pattern of ultrasound placental remodeling in patients with a history of SARS-CoV-2 infection during pregnancy. <b>Materials and Methods:</b> This was a longitudinal, cohort study which enrolled 23 pregnant wom...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/6/1200 |
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| author | Adelina Staicu Camelia Albu Georgiana Nemeti Cosmina Ioana Bondor Dan Boitor-Borza Andreia Paraschiva Preda Andreea Florian Iulian Gabriel Goidescu Diana Sachelaru Nelida Bora Roxana Constantin Mihai Surcel Florin Stamatian Ioana Cristina Rotar Gheorghe Cruciat Daniel Muresan |
| author_facet | Adelina Staicu Camelia Albu Georgiana Nemeti Cosmina Ioana Bondor Dan Boitor-Borza Andreia Paraschiva Preda Andreea Florian Iulian Gabriel Goidescu Diana Sachelaru Nelida Bora Roxana Constantin Mihai Surcel Florin Stamatian Ioana Cristina Rotar Gheorghe Cruciat Daniel Muresan |
| author_sort | Adelina Staicu |
| collection | DOAJ |
| description | <b>Introduction:</b> This research aims to describe a progressive pattern of ultrasound placental remodeling in patients with a history of SARS-CoV-2 infection during pregnancy. <b>Materials and Methods:</b> This was a longitudinal, cohort study which enrolled 23 pregnant women with a history of former mild SARS-CoV-2 infection during the current pregnancy. Four obstetricians analyzed placental ultrasound images from different gestational ages following COVID infection and identified the presence and degree of remodeling. We assessed the inter-rater agreement and the interclass correlation coefficients. Pathology workup included placental biometry, macroscopic and microscopic examination. <b>Results:</b> Serial ultrasound evaluation of the placental morphology revealed a progressive pattern of placental remodeling starting from 30–32 weeks of gestation towards term, occurring approximately 8–10 weeks after the SARS-CoV-2 infection. Placental changes—the “starry sky” appearance and the “white line” along the basal plate—were identified in all cases. Most placentas presented normal subchorionic perivillous fibrin depositions and focal stem villi perivillous fibrin deposits. Focal calcifications were described in only 13% of the cases. <b>Conclusions:</b> We identified two ultrasound signs of placental remodeling as potential markers of placental viral shedding following mild SARS-CoV-2. The most likely pathology correspondence for the imaging aspect is perivillous and, respectively, massive subchorionic fibrin deposits identified in most cases. |
| first_indexed | 2024-03-11T06:40:57Z |
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| id | doaj.art-890103bf42294774979e21f38e5d6c7f |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T06:40:57Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-890103bf42294774979e21f38e5d6c7f2023-11-17T10:35:43ZengMDPI AGDiagnostics2075-44182023-03-01136120010.3390/diagnostics13061200Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during PregnancyAdelina Staicu0Camelia Albu1Georgiana Nemeti2Cosmina Ioana Bondor3Dan Boitor-Borza4Andreia Paraschiva Preda5Andreea Florian6Iulian Gabriel Goidescu7Diana Sachelaru8Nelida Bora9Roxana Constantin10Mihai Surcel11Florin Stamatian12Ioana Cristina Rotar13Gheorghe Cruciat14Daniel Muresan15Obstetrics and Gynecology I, Mother and Child Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Pathology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Medical Informatics and Biostatistics, Iuliu Haţieganu University of Medicine and Pharmacy, 400347 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaObstetrics and Gynecology I Clinic, Emergency County Hospital, 400006 Cluj-Napoca, RomaniaObstetrics and Gynecology I Clinic, Emergency County Hospital, 400006 Cluj-Napoca, RomaniaObstetrics and Gynecology I Clinic, Emergency County Hospital, 400006 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaIMOGEN Centre of Advanced Research Studies, Emergency County Hospital, 400000 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaObstetrics and Gynecology I, Mother and Child Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania<b>Introduction:</b> This research aims to describe a progressive pattern of ultrasound placental remodeling in patients with a history of SARS-CoV-2 infection during pregnancy. <b>Materials and Methods:</b> This was a longitudinal, cohort study which enrolled 23 pregnant women with a history of former mild SARS-CoV-2 infection during the current pregnancy. Four obstetricians analyzed placental ultrasound images from different gestational ages following COVID infection and identified the presence and degree of remodeling. We assessed the inter-rater agreement and the interclass correlation coefficients. Pathology workup included placental biometry, macroscopic and microscopic examination. <b>Results:</b> Serial ultrasound evaluation of the placental morphology revealed a progressive pattern of placental remodeling starting from 30–32 weeks of gestation towards term, occurring approximately 8–10 weeks after the SARS-CoV-2 infection. Placental changes—the “starry sky” appearance and the “white line” along the basal plate—were identified in all cases. Most placentas presented normal subchorionic perivillous fibrin depositions and focal stem villi perivillous fibrin deposits. Focal calcifications were described in only 13% of the cases. <b>Conclusions:</b> We identified two ultrasound signs of placental remodeling as potential markers of placental viral shedding following mild SARS-CoV-2. The most likely pathology correspondence for the imaging aspect is perivillous and, respectively, massive subchorionic fibrin deposits identified in most cases.https://www.mdpi.com/2075-4418/13/6/1200prenatal ultrasoundSARS-CoV-2pregnancyplacental hyperechoic spotsCOVID-19fibrin deposits |
| spellingShingle | Adelina Staicu Camelia Albu Georgiana Nemeti Cosmina Ioana Bondor Dan Boitor-Borza Andreia Paraschiva Preda Andreea Florian Iulian Gabriel Goidescu Diana Sachelaru Nelida Bora Roxana Constantin Mihai Surcel Florin Stamatian Ioana Cristina Rotar Gheorghe Cruciat Daniel Muresan Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during Pregnancy Diagnostics prenatal ultrasound SARS-CoV-2 pregnancy placental hyperechoic spots COVID-19 fibrin deposits |
| title | Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during Pregnancy |
| title_full | Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during Pregnancy |
| title_fullStr | Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during Pregnancy |
| title_full_unstemmed | Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during Pregnancy |
| title_short | Ultrasound Placental Remodeling Patterns and Pathology Characteristics in Patients with History of Mild SARS-CoV-2 Infection during Pregnancy |
| title_sort | ultrasound placental remodeling patterns and pathology characteristics in patients with history of mild sars cov 2 infection during pregnancy |
| topic | prenatal ultrasound SARS-CoV-2 pregnancy placental hyperechoic spots COVID-19 fibrin deposits |
| url | https://www.mdpi.com/2075-4418/13/6/1200 |
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