Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study
<p>Abstract</p> <p>Background</p> <p>Haptoglobin (HP) is an acute phase protein that binds to freely circulating hemoglobin. HP exists as two distinct forms, HP1 and HP2. The longer HP2 form has been associated with cardiovascular (CVD) events and mortality in individua...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2013-02-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | http://www.cardiab.com/content/12/1/31 |
| _version_ | 1819036812083986432 |
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| author | Adams Jeremy N Cox Amanda J Freedman Barry I Langefeld Carl D Carr J Jeffrey Bowden Donald W |
| author_facet | Adams Jeremy N Cox Amanda J Freedman Barry I Langefeld Carl D Carr J Jeffrey Bowden Donald W |
| author_sort | Adams Jeremy N |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Haptoglobin (HP) is an acute phase protein that binds to freely circulating hemoglobin. HP exists as two distinct forms, HP1 and HP2. The longer HP2 form has been associated with cardiovascular (CVD) events and mortality in individuals with type 2 diabetes (T2DM).</p> <p>Methods</p> <p>This study examined the association of <it>HP</it> genotypes with subclinical CVD, T2DM risk, and associated risk factors in a T2DM-enriched sample. Haptoglobin genotypes were determined in 1208 European Americans (EA) from 473 Diabetes Heart Study (DHS) families via PCR. Three promoter SNPs (rs5467, rs5470, and rs5471) were also genotyped.</p> <p>Results</p> <p>Analyses revealed association between <it>HP2</it>-<it>2</it> duplication and increased carotid intima-media thickness (IMT; p = 0.001). No association between <it>HP</it> and measures of calcified arterial plaque were observed, but the <it>HP</it> polymorphism was associated with triglyceride concentrations (p = 0.005) and CVD mortality (p = 0.04). We found that the <it>HP2</it>-<it>2</it> genotype was associated with increased T2DM risk with an odds ratio (OR) of 1.49 (95% CI 1.18-1.86, p = 6.59x10<sup>-4</sup>). Promoter SNPs were not associated with any traits.</p> <p>Conclusions</p> <p>This study suggests association between the <it>HP</it> duplication and IMT, triglycerides, CVD mortality, and T2DM in an EA population enriched for T2DM. Lack of association with atherosclerotic calcified plaque likely reflect differences in the pathogenesis of these CVD phenotypes. <it>HP</it> variation may contribute to the heritable risk for CVD complications in T2DM.</p> |
| first_indexed | 2024-12-21T08:11:28Z |
| format | Article |
| id | doaj.art-8901c98a22174510b46e85605311f5ab |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-21T08:11:28Z |
| publishDate | 2013-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-8901c98a22174510b46e85605311f5ab2022-12-21T19:10:39ZengBMCCardiovascular Diabetology1475-28402013-02-011213110.1186/1475-2840-12-31Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart studyAdams Jeremy NCox Amanda JFreedman Barry ILangefeld Carl DCarr J JeffreyBowden Donald W<p>Abstract</p> <p>Background</p> <p>Haptoglobin (HP) is an acute phase protein that binds to freely circulating hemoglobin. HP exists as two distinct forms, HP1 and HP2. The longer HP2 form has been associated with cardiovascular (CVD) events and mortality in individuals with type 2 diabetes (T2DM).</p> <p>Methods</p> <p>This study examined the association of <it>HP</it> genotypes with subclinical CVD, T2DM risk, and associated risk factors in a T2DM-enriched sample. Haptoglobin genotypes were determined in 1208 European Americans (EA) from 473 Diabetes Heart Study (DHS) families via PCR. Three promoter SNPs (rs5467, rs5470, and rs5471) were also genotyped.</p> <p>Results</p> <p>Analyses revealed association between <it>HP2</it>-<it>2</it> duplication and increased carotid intima-media thickness (IMT; p = 0.001). No association between <it>HP</it> and measures of calcified arterial plaque were observed, but the <it>HP</it> polymorphism was associated with triglyceride concentrations (p = 0.005) and CVD mortality (p = 0.04). We found that the <it>HP2</it>-<it>2</it> genotype was associated with increased T2DM risk with an odds ratio (OR) of 1.49 (95% CI 1.18-1.86, p = 6.59x10<sup>-4</sup>). Promoter SNPs were not associated with any traits.</p> <p>Conclusions</p> <p>This study suggests association between the <it>HP</it> duplication and IMT, triglycerides, CVD mortality, and T2DM in an EA population enriched for T2DM. Lack of association with atherosclerotic calcified plaque likely reflect differences in the pathogenesis of these CVD phenotypes. <it>HP</it> variation may contribute to the heritable risk for CVD complications in T2DM.</p>http://www.cardiab.com/content/12/1/31HaptoglobinGenetic polymorphismCardiovascular diseaseType 2 diabetes |
| spellingShingle | Adams Jeremy N Cox Amanda J Freedman Barry I Langefeld Carl D Carr J Jeffrey Bowden Donald W Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study Cardiovascular Diabetology Haptoglobin Genetic polymorphism Cardiovascular disease Type 2 diabetes |
| title | Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study |
| title_full | Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study |
| title_fullStr | Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study |
| title_full_unstemmed | Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study |
| title_short | Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study |
| title_sort | genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study |
| topic | Haptoglobin Genetic polymorphism Cardiovascular disease Type 2 diabetes |
| url | http://www.cardiab.com/content/12/1/31 |
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