Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings
The use of silver nanoparticles (NPs) in medical devices is constantly increasing due to their excellent antimicrobial properties. In wound dressings, Ag NPs are commonly added in large excess to exert a long-term and constant antimicrobial effect, provoking an instantaneous release of Ag ions durin...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.987650/full |
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| author | V. Cazzagon E. Giubilato E. Giubilato A. Bonetto M. Blosi I. Zanoni A. L. Costa C. Vineis A. Varesano A. Marcomini D. Hristozov D. Hristozov E. Semenzin E. Badetti |
| author_facet | V. Cazzagon E. Giubilato E. Giubilato A. Bonetto M. Blosi I. Zanoni A. L. Costa C. Vineis A. Varesano A. Marcomini D. Hristozov D. Hristozov E. Semenzin E. Badetti |
| author_sort | V. Cazzagon |
| collection | DOAJ |
| description | The use of silver nanoparticles (NPs) in medical devices is constantly increasing due to their excellent antimicrobial properties. In wound dressings, Ag NPs are commonly added in large excess to exert a long-term and constant antimicrobial effect, provoking an instantaneous release of Ag ions during their use or the persistence of unused NPs in the wound dressing that can cause a release of Ag during the end-of-life of the product. For this reason, a Safe-by-Design procedure has been developed to reduce potential environmental risks while optimizing functionality and costs of wound dressings containing Ag NPs. The SbD procedure is based on ad-hoc criteria (e.g., mechanical strength, antibacterial effect, leaching of Ag from the product immersed in environmental media) and permits to identify the best one among five pre-market alternatives. A ranking of the SbD alternatives was obtained and the safer solution was selected based on the selected SbD criteria. The SbD framework was also applied to commercial wound dressings to compare the SbD alternatives with products already on the market. The iterative procedure permitted to exclude one of the alternatives (based on its low mechanical strength) and proved to be an effective approach that can be replicated to support the ranking, prioritisation, and selection of the most promising options early in the innovation process of nano-enabled medical devices as well as to encourage the production of medical devices safer for the environment. |
| first_indexed | 2024-04-13T18:22:37Z |
| format | Article |
| id | doaj.art-8902b5bca8b844b5b89475a37ca2ae8a |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-13T18:22:37Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-8902b5bca8b844b5b89475a37ca2ae8a2022-12-22T02:35:21ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-10-011010.3389/fbioe.2022.987650987650Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressingsV. Cazzagon0E. Giubilato1E. Giubilato2A. Bonetto3M. Blosi4I. Zanoni5A. L. Costa6C. Vineis7A. Varesano8A. Marcomini9D. Hristozov10D. Hristozov11E. Semenzin12E. Badetti13Department of Environmental Sciences Informatics and Statistics, Ca’ Foscari University of Venice, Venice Mestre, ItalyDepartment of Environmental Sciences Informatics and Statistics, Ca’ Foscari University of Venice, Venice Mestre, ItalyGreenDecision Srl, Venice Mestre, ItalyDepartment of Environmental Sciences Informatics and Statistics, Ca’ Foscari University of Venice, Venice Mestre, ItalyInstitute of Science and Technology for Ceramics (CNR-ISTEC), National Research Council of Italy, Faenza, ItalyInstitute of Science and Technology for Ceramics (CNR-ISTEC), National Research Council of Italy, Faenza, ItalyInstitute of Science and Technology for Ceramics (CNR-ISTEC), National Research Council of Italy, Faenza, ItalyInstitute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing (CNR-STIIMA), National Research Council of Italy, Biella, ItalyInstitute of Intelligent Industrial Technologies and Systems for Advanced Manufacturing (CNR-STIIMA), National Research Council of Italy, Biella, ItalyDepartment of Environmental Sciences Informatics and Statistics, Ca’ Foscari University of Venice, Venice Mestre, ItalyDepartment of Environmental Sciences Informatics and Statistics, Ca’ Foscari University of Venice, Venice Mestre, ItalyGreenDecision Srl, Venice Mestre, ItalyDepartment of Environmental Sciences Informatics and Statistics, Ca’ Foscari University of Venice, Venice Mestre, ItalyDepartment of Environmental Sciences Informatics and Statistics, Ca’ Foscari University of Venice, Venice Mestre, ItalyThe use of silver nanoparticles (NPs) in medical devices is constantly increasing due to their excellent antimicrobial properties. In wound dressings, Ag NPs are commonly added in large excess to exert a long-term and constant antimicrobial effect, provoking an instantaneous release of Ag ions during their use or the persistence of unused NPs in the wound dressing that can cause a release of Ag during the end-of-life of the product. For this reason, a Safe-by-Design procedure has been developed to reduce potential environmental risks while optimizing functionality and costs of wound dressings containing Ag NPs. The SbD procedure is based on ad-hoc criteria (e.g., mechanical strength, antibacterial effect, leaching of Ag from the product immersed in environmental media) and permits to identify the best one among five pre-market alternatives. A ranking of the SbD alternatives was obtained and the safer solution was selected based on the selected SbD criteria. The SbD framework was also applied to commercial wound dressings to compare the SbD alternatives with products already on the market. The iterative procedure permitted to exclude one of the alternatives (based on its low mechanical strength) and proved to be an effective approach that can be replicated to support the ranking, prioritisation, and selection of the most promising options early in the innovation process of nano-enabled medical devices as well as to encourage the production of medical devices safer for the environment.https://www.frontiersin.org/articles/10.3389/fbioe.2022.987650/fullsilverwound dressinganalytical chemistrysafe-by-designnanomaterialsmedical device |
| spellingShingle | V. Cazzagon E. Giubilato E. Giubilato A. Bonetto M. Blosi I. Zanoni A. L. Costa C. Vineis A. Varesano A. Marcomini D. Hristozov D. Hristozov E. Semenzin E. Badetti Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings Frontiers in Bioengineering and Biotechnology silver wound dressing analytical chemistry safe-by-design nanomaterials medical device |
| title | Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
| title_full | Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
| title_fullStr | Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
| title_full_unstemmed | Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
| title_short | Identification of the safe(r) by design alternatives for nanosilver-enabled wound dressings |
| title_sort | identification of the safe r by design alternatives for nanosilver enabled wound dressings |
| topic | silver wound dressing analytical chemistry safe-by-design nanomaterials medical device |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.987650/full |
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