Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis

Evaluation of neurofilament light chain in the cerebrospinal fluid and blood as a biomarker for neuronal damage in experimental pneumococcal meningitis

Abstract Background Pneumococcal meningitis (PM) remains a global public health concern and affects all age groups. If acquired during infancy or childhood, permanent neurofunctional deficits including cognitive impairment, cerebral palsy, and secondary epilepsy are typical sequelae of neuronal inju...

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Bibliographic Details
Main Authors: Ngoc Dung Le, Lukas Muri, Denis Grandgirard, Jens Kuhle, David Leppert, Stephen L. Leib
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
Pneumococcal meningitis
Neuroinflammation
Neuronal damage
Neurofilament light chain
Serum biomarker
Online Access:http://link.springer.com/article/10.1186/s12974-020-01966-3

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