IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues

IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues

Interleukin 11 (IL11) is upregulated in inflammatory conditions, where it is mostly believed to have anti-inflammatory activity. However, recent studies suggest instead that IL11 promotes inflammation by activating fibroblasts. Here, we assessed whether IL11 is pro- or anti-inflammatory in fibroblas...

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Bibliographic Details
Main Authors: Anissa A. Widjaja, Sonia Chothani, Sivakumar Viswanathan, Joyce Wei Ting Goh, Wei-Wen Lim, Stuart A. Cook
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
IL-33
IL-11
IL-6
fibrosis
fibroblasts
inflammation
Online Access:https://www.mdpi.com/1422-0067/23/16/8900

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