Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model
<i>Background and Objectives:</i> The major cause of vitamin D deficiency is inadequate exposure to sunlight. It is difficult to supplement it with food because sufficient concentrations of vitamin D naturally occur only in a handful of food products. Thereby, deficiency of this vitamin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-06-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/6/265 |
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| author | Egidijus Šimoliūnas Ieva Rinkūnaitė Živilė Bukelskienė Virginija Bukelskienė |
| author_facet | Egidijus Šimoliūnas Ieva Rinkūnaitė Živilė Bukelskienė Virginija Bukelskienė |
| author_sort | Egidijus Šimoliūnas |
| collection | DOAJ |
| description | <i>Background and Objectives:</i> The major cause of vitamin D deficiency is inadequate exposure to sunlight. It is difficult to supplement it with food because sufficient concentrations of vitamin D naturally occur only in a handful of food products. Thereby, deficiency of this vitamin is commonly corrected with oral supplements. Different supplement delivery systems for improved vitamin D stability and bioavailability are proposed. In this study, we compared efficiency of three vitamin D delivery systems: microencapsulated, micellized, and oil-based. <i>Materials and Methods:</i> As a model in this medical testing, laboratory rats were used for the evaluation of bioavailability of different vitamin D vehicles. Animals were divided into three groups: the first one was given microencapsulated vitamin D<sub>3</sub>, the second—oil-based vitamin D<sub>3</sub>, and the third—micellized vitamin D<sub>3</sub>. Test substances were given <i>per os</i> to each animal for 7 days, and vitamin D concentration in a form of 25-hydroxyvitamin D (25(OH)D) in the blood was checked both during the vitamin delivery period and later, up to the 24th day. <i>Results:</i> Comparison of all three tested products showed that the microencapsulated and oil-based vitamin D<sub>3</sub> vehicles were the most bioavailable in comparison to micellized vitamin D<sub>3</sub>. Even more, the effect of the microencapsulated form of vitamin D<sub>3</sub> remained constant for the longest period (up to 14 days). <i>Conclusions:</i> The results of this study suggest that the oral vitamin D supplement vehicle has an impact on its bioavailability, thus it is important to take into account how much of the suppled vitamin D will be absorbed. To maximize the full exploit of supplement, the best delivery strategy should be employed. In our study, the microencapsulated form of vitamin D was the most bioavailable. |
| first_indexed | 2024-03-12T06:45:20Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T06:45:20Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-8905a1eab8a94bce8c860ba95ebc25be2023-09-03T00:35:12ZengMDPI AGMedicina1010-660X2019-06-0155626510.3390/medicina55060265medicina55060265Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal ModelEgidijus Šimoliūnas0Ieva Rinkūnaitė1Živilė Bukelskienė2Virginija Bukelskienė3Institute of Biochemistry, Life Sciences Center, Vilnius University, LT- 10257 Vilnius, LithuaniaInstitute of Biochemistry, Life Sciences Center, Vilnius University, LT- 10257 Vilnius, LithuaniaPublic Institution Vilnius Centro Outpatient Clinic, LT-01117 Vilnius, LithuaniaInstitute of Biochemistry, Life Sciences Center, Vilnius University, LT- 10257 Vilnius, Lithuania<i>Background and Objectives:</i> The major cause of vitamin D deficiency is inadequate exposure to sunlight. It is difficult to supplement it with food because sufficient concentrations of vitamin D naturally occur only in a handful of food products. Thereby, deficiency of this vitamin is commonly corrected with oral supplements. Different supplement delivery systems for improved vitamin D stability and bioavailability are proposed. In this study, we compared efficiency of three vitamin D delivery systems: microencapsulated, micellized, and oil-based. <i>Materials and Methods:</i> As a model in this medical testing, laboratory rats were used for the evaluation of bioavailability of different vitamin D vehicles. Animals were divided into three groups: the first one was given microencapsulated vitamin D<sub>3</sub>, the second—oil-based vitamin D<sub>3</sub>, and the third—micellized vitamin D<sub>3</sub>. Test substances were given <i>per os</i> to each animal for 7 days, and vitamin D concentration in a form of 25-hydroxyvitamin D (25(OH)D) in the blood was checked both during the vitamin delivery period and later, up to the 24th day. <i>Results:</i> Comparison of all three tested products showed that the microencapsulated and oil-based vitamin D<sub>3</sub> vehicles were the most bioavailable in comparison to micellized vitamin D<sub>3</sub>. Even more, the effect of the microencapsulated form of vitamin D<sub>3</sub> remained constant for the longest period (up to 14 days). <i>Conclusions:</i> The results of this study suggest that the oral vitamin D supplement vehicle has an impact on its bioavailability, thus it is important to take into account how much of the suppled vitamin D will be absorbed. To maximize the full exploit of supplement, the best delivery strategy should be employed. In our study, the microencapsulated form of vitamin D was the most bioavailable.https://www.mdpi.com/1010-660X/55/6/265vitamin Doral supplementsvehiclebioavailabilityvitamin D deficiency |
| spellingShingle | Egidijus Šimoliūnas Ieva Rinkūnaitė Živilė Bukelskienė Virginija Bukelskienė Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model Medicina vitamin D oral supplements vehicle bioavailability vitamin D deficiency |
| title | Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model |
| title_full | Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model |
| title_fullStr | Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model |
| title_full_unstemmed | Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model |
| title_short | Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model |
| title_sort | bioavailability of different vitamin d oral supplements in laboratory animal model |
| topic | vitamin D oral supplements vehicle bioavailability vitamin D deficiency |
| url | https://www.mdpi.com/1010-660X/55/6/265 |
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