The Role of GITR/GITRL Interaction in Autoimmune Diseases
Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily which is expressed in various cells, including T cells, natural killer cells and some myeloid cells. GITR is activated by its ligand, GITRL, mainly expressed on antigen presenting cells and endothelial cells. It h...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-10-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.588682/full |
| _version_ | 1819006951836614656 |
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| author | Jie Tian Jie Tian Beibei Zhang Ke Rui Shengjun Wang Shengjun Wang |
| author_facet | Jie Tian Jie Tian Beibei Zhang Ke Rui Shengjun Wang Shengjun Wang |
| author_sort | Jie Tian |
| collection | DOAJ |
| description | Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily which is expressed in various cells, including T cells, natural killer cells and some myeloid cells. GITR is activated by its ligand, GITRL, mainly expressed on antigen presenting cells and endothelial cells. It has been acknowledged that the engagement of GITR can modulate both innate and adaptive immune responses. Accumulated evidence suggests GITR/GITRL interaction is involved in the pathogenesis of tumor, inflammation and autoimmune diseases. In this review, we describe the effects of GITR/GITRL activation on effector T cells, regulatory T cells (Tregs) and myeloid cells; summarize its role and the underlying mechanisms in modulating autoimmune diseases. |
| first_indexed | 2024-12-21T00:16:51Z |
| format | Article |
| id | doaj.art-890861fcb09b45c3b0257b7c143106e0 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T00:16:51Z |
| publishDate | 2020-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-890861fcb09b45c3b0257b7c143106e02022-12-21T19:22:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-10-011110.3389/fimmu.2020.588682588682The Role of GITR/GITRL Interaction in Autoimmune DiseasesJie Tian0Jie Tian1Beibei Zhang2Ke Rui3Shengjun Wang4Shengjun Wang5Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, ChinaDepartment of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaDepartment of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, ChinaDepartment of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Zhenjiang, ChinaDepartment of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, ChinaGlucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily which is expressed in various cells, including T cells, natural killer cells and some myeloid cells. GITR is activated by its ligand, GITRL, mainly expressed on antigen presenting cells and endothelial cells. It has been acknowledged that the engagement of GITR can modulate both innate and adaptive immune responses. Accumulated evidence suggests GITR/GITRL interaction is involved in the pathogenesis of tumor, inflammation and autoimmune diseases. In this review, we describe the effects of GITR/GITRL activation on effector T cells, regulatory T cells (Tregs) and myeloid cells; summarize its role and the underlying mechanisms in modulating autoimmune diseases.https://www.frontiersin.org/article/10.3389/fimmu.2020.588682/fullglucocorticoid-induced TNFR-related proteinGITRLT cellmyeloid cellsautoimmune diseases |
| spellingShingle | Jie Tian Jie Tian Beibei Zhang Ke Rui Shengjun Wang Shengjun Wang The Role of GITR/GITRL Interaction in Autoimmune Diseases Frontiers in Immunology glucocorticoid-induced TNFR-related protein GITRL T cell myeloid cells autoimmune diseases |
| title | The Role of GITR/GITRL Interaction in Autoimmune Diseases |
| title_full | The Role of GITR/GITRL Interaction in Autoimmune Diseases |
| title_fullStr | The Role of GITR/GITRL Interaction in Autoimmune Diseases |
| title_full_unstemmed | The Role of GITR/GITRL Interaction in Autoimmune Diseases |
| title_short | The Role of GITR/GITRL Interaction in Autoimmune Diseases |
| title_sort | role of gitr gitrl interaction in autoimmune diseases |
| topic | glucocorticoid-induced TNFR-related protein GITRL T cell myeloid cells autoimmune diseases |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.588682/full |
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