Podoplanin (PDPN) affects the invasiveness of thyroid carcinoma cells by inducing ezrin, radixin and moesin (E/R/M) phosphorylation in association with matrix metalloproteinases

Podoplanin (PDPN) affects the invasiveness of thyroid carcinoma cells by inducing ezrin, radixin and moesin (E/R/M) phosphorylation in association with matrix metalloproteinases

Abstract Background Podoplanin (PDPN) is a mucin-type transmembrane glycoprotein specific to the lymphatic system. PDPN expression has been found in various human tumors and is considered to be a marker of cancer. We had previously shown that PDPN expression contributes to carcinogenesis in the TPC1...

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Bibliographic Details
Main Authors: Justyna Sikorska, Damian Gaweł, Hanna Domek, Magdalena Rudzińska, Barbara Czarnocka
Format: Article
Language:English
Published: BMC 2019-01-01
Series:BMC Cancer
Subjects:
Podoplanin
TPC1
BcPAP
Ezrin/radixin/moesin
Metalloproteinases
Motility
Online Access:http://link.springer.com/article/10.1186/s12885-018-5239-z

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