A Dominant-Negative Mutant of ANXA7 Impairs Calcium Signaling and Enhances the Proliferation of Prostate Cancer Cells by Downregulating the IP3 Receptor and the PI3K/mTOR Pathway

A Dominant-Negative Mutant of ANXA7 Impairs Calcium Signaling and Enhances the Proliferation of Prostate Cancer Cells by Downregulating the IP3 Receptor and the PI3K/mTOR Pathway

Annexin A7/ANXA7 is a calcium-dependent membrane fusion protein with tumor suppressor gene (TSG) properties, which is located on chromosome 10q21 and is thought to function in the regulation of calcium homeostasis and tumorigenesis. However, whether the molecular mechanisms for tumor suppression are...

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Bibliographic Details
Main Authors: Meera Srivastava, Alakesh Bera, Ofer Eidelman, Minh B. Tran, Catherine Jozwik, Mirta Glasman, Ximena Leighton, Hung Caohuy, Harvey B. Pollard
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
ANXA7
dominant-negative triple mutant (DNTM)
IP3
mTOR
PI3K
Online Access:https://www.mdpi.com/1422-0067/24/10/8818

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