Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution study
Abstract Background Tyrosine kinase inhibitors (TKIs) such as cabozantinib, regorafenib have demonstrated encouraging activity in prolonging progression‐free survival (PFS) in several bone sarcoma entities in prospective clinical trials. This retrospective study aims to analyze the safety and effica...
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| Format: | Article |
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Wiley
2021-11-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.4286 |
| _version_ | 1818693566130552832 |
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| author | Zhiyong Liu Songtao Gao Liangyu Zhu Jiaqiang Wang Peng Zhang Po Li Fan Zhang Weitao Yao |
| author_facet | Zhiyong Liu Songtao Gao Liangyu Zhu Jiaqiang Wang Peng Zhang Po Li Fan Zhang Weitao Yao |
| author_sort | Zhiyong Liu |
| collection | DOAJ |
| description | Abstract Background Tyrosine kinase inhibitors (TKIs) such as cabozantinib, regorafenib have demonstrated encouraging activity in prolonging progression‐free survival (PFS) in several bone sarcoma entities in prospective clinical trials. This retrospective study aims to analyze the safety and efficacy of anlotinib, a novel multi‐target TKI, in patients with locally unresectable or metastatic bone sarcoma at three institutions. Methods Patients with advanced bone sarcoma administered anlotinib 12 mg once daily, 2 weeks on/1 week off, from June 2018 to June 2020, until disease progression or intolerance of treatment. The primary endpoints were objective response rate (ORR) and PFS. Results Forty‐eight patients were analyzed: 27 have osteosarcoma, 9 have chondrosarcoma, 8 have Ewing's sarcoma, and 3 have chordoma. The median age was 24 years (range, 16–68 years), and the median number of prior regimens was 1 (range, 0–4). Until the final follow‐up, five patients obtained a partial response and while 24 achieved stable disease. The ORR in all patients was 10.4%, and the median PFS was 4.6 months, with a progression‐free rate (PFR) at 3 months and 6 months of 72.9% and 35.4%, respectively. The ORR and median PFS varied much among tumor subtypes. The most frequent grade 3–4 adverse events (AEs) were pneumothorax, hand‐foot syndrome, cholesterol elevation, hypertriglyceridemia, and fatigue. No patients died from anlotinib‐related AEs during the study period. Conclusions Anlotinib may show promising antitumor activity in unresectable or metastatic bone sarcoma. The ORR and median PFS of anlotnib are similar to those of other targeted drugs in different subtypes of sarcomas. The AEs were generally mild and tolerated well. Further studies of anlotinib in selected subtypes of bone sarcoma are needed. |
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| id | doaj.art-8909f8b6b0e34220b8bcb6367e341ec4 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-12-17T13:15:43Z |
| publishDate | 2021-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-8909f8b6b0e34220b8bcb6367e341ec42022-12-21T21:46:59ZengWileyCancer Medicine2045-76342021-11-0110217593760010.1002/cam4.4286Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution studyZhiyong Liu0Songtao Gao1Liangyu Zhu2Jiaqiang Wang3Peng Zhang4Po Li5Fan Zhang6Weitao Yao7Department of Orthopedics The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan ChinaDepartment of Orthopedics Henan Provincial People's Hospital and People's Hospital of Zhengzhou University Zhengzhou Henan ChinaDepartment of Orthopedics Zhengzhou Orthopedics Hospital Zhengzhou Henan ChinaDepartment of Orthopedics The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan ChinaDepartment of Orthopedics The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan ChinaDepartment of Orthopedics The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan ChinaDepartment of Orthopedics The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan ChinaDepartment of Orthopedics The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan ChinaAbstract Background Tyrosine kinase inhibitors (TKIs) such as cabozantinib, regorafenib have demonstrated encouraging activity in prolonging progression‐free survival (PFS) in several bone sarcoma entities in prospective clinical trials. This retrospective study aims to analyze the safety and efficacy of anlotinib, a novel multi‐target TKI, in patients with locally unresectable or metastatic bone sarcoma at three institutions. Methods Patients with advanced bone sarcoma administered anlotinib 12 mg once daily, 2 weeks on/1 week off, from June 2018 to June 2020, until disease progression or intolerance of treatment. The primary endpoints were objective response rate (ORR) and PFS. Results Forty‐eight patients were analyzed: 27 have osteosarcoma, 9 have chondrosarcoma, 8 have Ewing's sarcoma, and 3 have chordoma. The median age was 24 years (range, 16–68 years), and the median number of prior regimens was 1 (range, 0–4). Until the final follow‐up, five patients obtained a partial response and while 24 achieved stable disease. The ORR in all patients was 10.4%, and the median PFS was 4.6 months, with a progression‐free rate (PFR) at 3 months and 6 months of 72.9% and 35.4%, respectively. The ORR and median PFS varied much among tumor subtypes. The most frequent grade 3–4 adverse events (AEs) were pneumothorax, hand‐foot syndrome, cholesterol elevation, hypertriglyceridemia, and fatigue. No patients died from anlotinib‐related AEs during the study period. Conclusions Anlotinib may show promising antitumor activity in unresectable or metastatic bone sarcoma. The ORR and median PFS of anlotnib are similar to those of other targeted drugs in different subtypes of sarcomas. The AEs were generally mild and tolerated well. Further studies of anlotinib in selected subtypes of bone sarcoma are needed.https://doi.org/10.1002/cam4.4286anlotinibbone sarcomaprogression‐free survivalsafety |
| spellingShingle | Zhiyong Liu Songtao Gao Liangyu Zhu Jiaqiang Wang Peng Zhang Po Li Fan Zhang Weitao Yao Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution study Cancer Medicine anlotinib bone sarcoma progression‐free survival safety |
| title | Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution study |
| title_full | Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution study |
| title_fullStr | Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution study |
| title_full_unstemmed | Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution study |
| title_short | Efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma: A retrospective multiple institution study |
| title_sort | efficacy and safety of anlotinib in patients with unresectable or metastatic bone sarcoma a retrospective multiple institution study |
| topic | anlotinib bone sarcoma progression‐free survival safety |
| url | https://doi.org/10.1002/cam4.4286 |
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