Investigating the Physical Effects in Bacterial Therapies for Avascular Tumors
Tumor-targeting bacteria elicit anticancer effects by infiltrating hypoxic regions, releasing toxic agents and inducing immune responses. Although current research has largely focused on the influence of chemical and immunological aspects on the mechanisms of bacterial therapy, the impact of physica...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2020.01083/full |
| _version_ | 1818272725752348672 |
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| author | Pietro Mascheroni Michael Meyer-Hermann Michael Meyer-Hermann Michael Meyer-Hermann Haralampos Hatzikirou |
| author_facet | Pietro Mascheroni Michael Meyer-Hermann Michael Meyer-Hermann Michael Meyer-Hermann Haralampos Hatzikirou |
| author_sort | Pietro Mascheroni |
| collection | DOAJ |
| description | Tumor-targeting bacteria elicit anticancer effects by infiltrating hypoxic regions, releasing toxic agents and inducing immune responses. Although current research has largely focused on the influence of chemical and immunological aspects on the mechanisms of bacterial therapy, the impact of physical effects is still elusive. Here, we propose a mathematical model for the anti-tumor activity of bacteria in avascular tumors that takes into account the relevant chemo-mechanical effects. We consider a time-dependent administration of bacteria and analyze the impact of bacterial chemotaxis and killing rate. We show that active bacterial migration toward tumor hypoxic regions provides optimal infiltration and that high killing rates combined with high chemotactic values provide the smallest tumor volumes at the end of the treatment. We highlight the emergence of steady states in which a small population of bacteria is able to constrain tumor growth. Finally, we show that bacteria treatment works best in the case of tumors with high cellular proliferation and low oxygen consumption. |
| first_indexed | 2024-12-12T21:46:38Z |
| format | Article |
| id | doaj.art-890a7ae2e9d54a8392d1dc2398112648 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T21:46:38Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-890a7ae2e9d54a8392d1dc23981126482022-12-22T00:10:54ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-06-011110.3389/fmicb.2020.01083536915Investigating the Physical Effects in Bacterial Therapies for Avascular TumorsPietro Mascheroni0Michael Meyer-Hermann1Michael Meyer-Hermann2Michael Meyer-Hermann3Haralampos Hatzikirou4Braunschweig Integrated Centre of Systems Biology and Helmholtz Centre for Infection Research, Braunschweig, GermanyBraunschweig Integrated Centre of Systems Biology and Helmholtz Centre for Infection Research, Braunschweig, GermanyCentre for Individualized Infection Medicine, Hannover, GermanyInstitute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, GermanyBraunschweig Integrated Centre of Systems Biology and Helmholtz Centre for Infection Research, Braunschweig, GermanyTumor-targeting bacteria elicit anticancer effects by infiltrating hypoxic regions, releasing toxic agents and inducing immune responses. Although current research has largely focused on the influence of chemical and immunological aspects on the mechanisms of bacterial therapy, the impact of physical effects is still elusive. Here, we propose a mathematical model for the anti-tumor activity of bacteria in avascular tumors that takes into account the relevant chemo-mechanical effects. We consider a time-dependent administration of bacteria and analyze the impact of bacterial chemotaxis and killing rate. We show that active bacterial migration toward tumor hypoxic regions provides optimal infiltration and that high killing rates combined with high chemotactic values provide the smallest tumor volumes at the end of the treatment. We highlight the emergence of steady states in which a small population of bacteria is able to constrain tumor growth. Finally, we show that bacteria treatment works best in the case of tumors with high cellular proliferation and low oxygen consumption.https://www.frontiersin.org/article/10.3389/fmicb.2020.01083/fullcancerbacterial therapymathematical modelingchemotaxisspace competition |
| spellingShingle | Pietro Mascheroni Michael Meyer-Hermann Michael Meyer-Hermann Michael Meyer-Hermann Haralampos Hatzikirou Investigating the Physical Effects in Bacterial Therapies for Avascular Tumors Frontiers in Microbiology cancer bacterial therapy mathematical modeling chemotaxis space competition |
| title | Investigating the Physical Effects in Bacterial Therapies for Avascular Tumors |
| title_full | Investigating the Physical Effects in Bacterial Therapies for Avascular Tumors |
| title_fullStr | Investigating the Physical Effects in Bacterial Therapies for Avascular Tumors |
| title_full_unstemmed | Investigating the Physical Effects in Bacterial Therapies for Avascular Tumors |
| title_short | Investigating the Physical Effects in Bacterial Therapies for Avascular Tumors |
| title_sort | investigating the physical effects in bacterial therapies for avascular tumors |
| topic | cancer bacterial therapy mathematical modeling chemotaxis space competition |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2020.01083/full |
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