Multiple functions of cold-inducible RNA-binding protein in biological systems
Cold-inducible RNA-binding protein (CIRP) is an 18-kDa nuclear protein belonging to the family of cold-shock proteins. It is widely expressed in various tissues and upregulated in response to various cellular stresses. Originally, CIRP was found to stabilize specific mRNAs to facilitate their transl...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Vascular Investigation and Therapy |
| Subjects: | |
| Online Access: | http://www.vitonline.org/article.asp?issn=2589-9686;year=2019;volume=2;issue=3;spage=73;epage=77;aulast=Li |
| _version_ | 1818454297958940672 |
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| author | Gang Li Peixian Gao Kun Luo Hua Zhou Yuxiang He Hai Yuan Xuejun Wu |
| author_facet | Gang Li Peixian Gao Kun Luo Hua Zhou Yuxiang He Hai Yuan Xuejun Wu |
| author_sort | Gang Li |
| collection | DOAJ |
| description | Cold-inducible RNA-binding protein (CIRP) is an 18-kDa nuclear protein belonging to the family of cold-shock proteins. It is widely expressed in various tissues and upregulated in response to various cellular stresses. Originally, CIRP was found to stabilize specific mRNAs to facilitate their translation, which results in a survival advantage for cells under stress. Hypothermia-induced CIRP has been shown to protect the neuronal system. Recently, CIRP was found to be a multifunctional protein. In addition to acting as a damage-associated molecular pattern molecule to promote inflammation, it was also found to affect tumorigenesis. CIRP was also found to regulate telomerase activity and cardiac repolarization. Therefore, biological activities of CIRP in novel systems should receive more attention. This review will provide a brief introduction to the recent studies of CIRP with the aim of inspiring future research of novel CIRP functions. |
| first_indexed | 2024-12-14T21:52:39Z |
| format | Article |
| id | doaj.art-890b062cf8a1499da0432b4cf9e0ffa4 |
| institution | Directory Open Access Journal |
| issn | 2589-9686 2589-9481 |
| language | English |
| last_indexed | 2024-12-14T21:52:39Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Vascular Investigation and Therapy |
| spelling | doaj.art-890b062cf8a1499da0432b4cf9e0ffa42022-12-21T22:46:12ZengWolters Kluwer Medknow PublicationsVascular Investigation and Therapy2589-96862589-94812019-01-0123737710.4103/VIT.VIT_13_19Multiple functions of cold-inducible RNA-binding protein in biological systemsGang LiPeixian GaoKun LuoHua ZhouYuxiang HeHai YuanXuejun WuCold-inducible RNA-binding protein (CIRP) is an 18-kDa nuclear protein belonging to the family of cold-shock proteins. It is widely expressed in various tissues and upregulated in response to various cellular stresses. Originally, CIRP was found to stabilize specific mRNAs to facilitate their translation, which results in a survival advantage for cells under stress. Hypothermia-induced CIRP has been shown to protect the neuronal system. Recently, CIRP was found to be a multifunctional protein. In addition to acting as a damage-associated molecular pattern molecule to promote inflammation, it was also found to affect tumorigenesis. CIRP was also found to regulate telomerase activity and cardiac repolarization. Therefore, biological activities of CIRP in novel systems should receive more attention. This review will provide a brief introduction to the recent studies of CIRP with the aim of inspiring future research of novel CIRP functions.http://www.vitonline.org/article.asp?issn=2589-9686;year=2019;volume=2;issue=3;spage=73;epage=77;aulast=Licold-inducible rna-binding proteininflammationstresstumorigenesis |
| spellingShingle | Gang Li Peixian Gao Kun Luo Hua Zhou Yuxiang He Hai Yuan Xuejun Wu Multiple functions of cold-inducible RNA-binding protein in biological systems Vascular Investigation and Therapy cold-inducible rna-binding protein inflammation stress tumorigenesis |
| title | Multiple functions of cold-inducible RNA-binding protein in biological systems |
| title_full | Multiple functions of cold-inducible RNA-binding protein in biological systems |
| title_fullStr | Multiple functions of cold-inducible RNA-binding protein in biological systems |
| title_full_unstemmed | Multiple functions of cold-inducible RNA-binding protein in biological systems |
| title_short | Multiple functions of cold-inducible RNA-binding protein in biological systems |
| title_sort | multiple functions of cold inducible rna binding protein in biological systems |
| topic | cold-inducible rna-binding protein inflammation stress tumorigenesis |
| url | http://www.vitonline.org/article.asp?issn=2589-9686;year=2019;volume=2;issue=3;spage=73;epage=77;aulast=Li |
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