Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year Experience at JCI Accredited Tertiary Care Hospital in Pakistan
Background: Compact cyclotrons are getting popular to fulfill enormous current demands of PET tracers. Aga Khan University Hospital, Karachi, Pakistan has acquired the first smallest footprint of BG-75 Generator for 18FDG-based PET/CT clinical imaging. We are sharing our experience of BG-75 in the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2019-08-01
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| Series: | Journal of Biomedical Physics and Engineering |
| Subjects: | |
| Online Access: | http://jbpe.ir/Journal_OJS/JBPE/index.php/jbpe/article/view/792/457 |
| Summary: | Background: Compact cyclotrons are getting popular to fulfill enormous current demands of PET tracers. Aga Khan University Hospital, Karachi, Pakistan has
acquired the first smallest footprint of BG-75 Generator for 18FDG-based PET/CT
clinical imaging. We are sharing our experience of BG-75 in the first year (December
2015-November 2016) after commissioning.
Material and Methods: BG-75 Generator (ABT, USA) was installed in available space without major design modification. It has a self-shielded mini-cyclotron
(7.5 MeV proton beam, positive ion with current < 5µA) to produce [18F]F-, an
automated card-based radiochemistry module to produce 18FDG and automated QC
module to perform tests upon each batch of 18FDG. Data were collected for yields of
[18F]F-, 18FDG, QC and radiation safety parameters.
Results: Total 545 runs in 167 days (3±01 runs/day) were made. Average yield
with 60 minute bombardment using 4.5 µA current was 37 mCi and 21 mCi for [18F]
F- and 18FDG, respectively. Total 29 runs had chemistry or QC failures and were
discarded. Remaining 516 batches were used to perform imaging upon 1370 patients
(8±03 patients/day). Radiation dose in BG-75 suite and effective doses to 02 operators were within statutory limits.
Conclusion: BG-75 Generator provides safe, dependable and sustainable supply
of 18F-Fluoride for 18FDG and other low-volume clinical PET imaging. Its compactness and automation need minimal space and manpower. Radiation dose rate in
cyclotron suite and personal dosimetry were also found within safe limits. Its Doseon-Demand workflow offers a new concept of Personalized Dose Preparation which
is currently not possible with a conventional cyclotron.
Citation: Zaman M. U, Fatima N, Mehdi S. U, Sami M, Khan Kh, Khan G. Personalized 18FDG Dose Synthesis Using BG-75 Generator: 1st Year
Experience at JCI Accredited Tertiary Care Hospital in Pakistan. J Biomed Phys Eng. 2019;9(4):409-416. https://doi.org/10.31661/jbpe.v0i0.792 |
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| ISSN: | 2251-7200 2251-7200 |