Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine
This work concerns the production of fibrous composite materials based on biodegradable polymers such as alginate, dibutyryl chitin (DBC) and poly-ε-caprolactone (PCL). For the production of fibres from these polymers, various spinning methods were used in order to obtain composite materials of diff...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-03-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/3/3118 |
| _version_ | 1818766269788192768 |
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| author | Elżbieta Menaszek Ewa Stodolak-Zych Marta Błażewicz Teresa Mikołajczyk Izabella Krucińska Agnieszka Kommisarczyk Maciej Boguń Anna Ścisłowska-Czarnecka |
| author_facet | Elżbieta Menaszek Ewa Stodolak-Zych Marta Błażewicz Teresa Mikołajczyk Izabella Krucińska Agnieszka Kommisarczyk Maciej Boguń Anna Ścisłowska-Czarnecka |
| author_sort | Elżbieta Menaszek |
| collection | DOAJ |
| description | This work concerns the production of fibrous composite materials based on biodegradable polymers such as alginate, dibutyryl chitin (DBC) and poly-ε-caprolactone (PCL). For the production of fibres from these polymers, various spinning methods were used in order to obtain composite materials of different composition and structure. In the case of alginate fibres containing the nanoadditive tricalcium phosphate (TCP), the traditional method of forming fibres wet from solution was used. However in the case of the other two polymers the electrospinning method was used. Two model systems were tested for biocompatibility. The physicochemical and basic biological tests carried out show that the submicron fibres produced using PCL and DBC have good biocompatibility. The proposed hybrid systems composed of micrometric fibres (zinc and calcium alginates containing TCP) and submicron fibres (DBC and PCL) meet the requirements of regenerative medicine. The biomimetic fibre system, the presence of TCP nanoadditive, and the use of polymers with different resorption times provide a framework with specific properties on which bone cells are able to settle and proliferate. |
| first_indexed | 2024-12-18T08:31:19Z |
| format | Article |
| id | doaj.art-890c77289a364b91aefdf6c61c35177f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-18T08:31:19Z |
| publishDate | 2013-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-890c77289a364b91aefdf6c61c35177f2022-12-21T21:14:27ZengMDPI AGMolecules1420-30492013-03-011833118313610.3390/molecules18033118Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative MedicineElżbieta MenaszekEwa Stodolak-ZychMarta BłażewiczTeresa MikołajczykIzabella KrucińskaAgnieszka KommisarczykMaciej BoguńAnna Ścisłowska-CzarneckaThis work concerns the production of fibrous composite materials based on biodegradable polymers such as alginate, dibutyryl chitin (DBC) and poly-ε-caprolactone (PCL). For the production of fibres from these polymers, various spinning methods were used in order to obtain composite materials of different composition and structure. In the case of alginate fibres containing the nanoadditive tricalcium phosphate (TCP), the traditional method of forming fibres wet from solution was used. However in the case of the other two polymers the electrospinning method was used. Two model systems were tested for biocompatibility. The physicochemical and basic biological tests carried out show that the submicron fibres produced using PCL and DBC have good biocompatibility. The proposed hybrid systems composed of micrometric fibres (zinc and calcium alginates containing TCP) and submicron fibres (DBC and PCL) meet the requirements of regenerative medicine. The biomimetic fibre system, the presence of TCP nanoadditive, and the use of polymers with different resorption times provide a framework with specific properties on which bone cells are able to settle and proliferate.http://www.mdpi.com/1420-3049/18/3/3118dibutyryl chitinpoly-ε-caprolactonealginate fibresbiodegradable polymers |
| spellingShingle | Elżbieta Menaszek Ewa Stodolak-Zych Marta Błażewicz Teresa Mikołajczyk Izabella Krucińska Agnieszka Kommisarczyk Maciej Boguń Anna Ścisłowska-Czarnecka Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine Molecules dibutyryl chitin poly-ε-caprolactone alginate fibres biodegradable polymers |
| title | Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine |
| title_full | Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine |
| title_fullStr | Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine |
| title_full_unstemmed | Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine |
| title_short | Fibrous Polymeric Composites Based on Alginate Fibres and Fibres Made of Poly-ε-caprolactone and Dibutyryl Chitin for Use in Regenerative Medicine |
| title_sort | fibrous polymeric composites based on alginate fibres and fibres made of poly ε caprolactone and dibutyryl chitin for use in regenerative medicine |
| topic | dibutyryl chitin poly-ε-caprolactone alginate fibres biodegradable polymers |
| url | http://www.mdpi.com/1420-3049/18/3/3118 |
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