How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data
Abstract In spite of many genetic studies that contributed for a deep knowledge about the peopling of the Americas, no consensus has emerged about important parameters such as the effective size of the Native Americans founder population. Previous estimates based on genomic datasets may have been bi...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
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| Series: | Genetics and Molecular Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200206&lng=en&tlng=en |
| _version_ | 1818985500470411264 |
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| author | Nelson J.R. Fagundes Alice Tagliani-Ribeiro Rohina Rubicz Larissa Tarskaia Michael H. Crawford Francisco M. Salzano Sandro L. Bonatto |
| author_facet | Nelson J.R. Fagundes Alice Tagliani-Ribeiro Rohina Rubicz Larissa Tarskaia Michael H. Crawford Francisco M. Salzano Sandro L. Bonatto |
| author_sort | Nelson J.R. Fagundes |
| collection | DOAJ |
| description | Abstract In spite of many genetic studies that contributed for a deep knowledge about the peopling of the Americas, no consensus has emerged about important parameters such as the effective size of the Native Americans founder population. Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from Latino populations, while other recent studies using samples from Native American individuals relied on approximated analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting for recent flow between Asian and Native American populations. Our results suggest that, in agreement with previous studies, the effective size of the Native American population was small, most likely in the order of a few hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as large as ~4,000 individuals. Recognizing the size of the genetic bottleneck during the peopling of the Americas is important for determining the extent of genetic markers needed to characterize Native American populations in genome-wide studies and to evaluate the adaptive potential of genetic variants in this population. |
| first_indexed | 2024-12-20T18:35:53Z |
| format | Article |
| id | doaj.art-890de7eabf9b4658b8ce208d6641178c |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-12-20T18:35:53Z |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-890de7eabf9b4658b8ce208d6641178c2022-12-21T19:29:56ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-4685411 suppl 120621410.1590/1678-4685-gmb-2017-0087S1415-47572018000200206How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence dataNelson J.R. FagundesAlice Tagliani-RibeiroRohina RubiczLarissa TarskaiaMichael H. CrawfordFrancisco M. SalzanoSandro L. BonattoAbstract In spite of many genetic studies that contributed for a deep knowledge about the peopling of the Americas, no consensus has emerged about important parameters such as the effective size of the Native Americans founder population. Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from Latino populations, while other recent studies using samples from Native American individuals relied on approximated analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting for recent flow between Asian and Native American populations. Our results suggest that, in agreement with previous studies, the effective size of the Native American population was small, most likely in the order of a few hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as large as ~4,000 individuals. Recognizing the size of the genetic bottleneck during the peopling of the Americas is important for determining the extent of genetic markers needed to characterize Native American populations in genome-wide studies and to evaluate the adaptive potential of genetic variants in this population.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200206&lng=en&tlng=enIsolation with Migration modelcoalescent analysisnative Siberians |
| spellingShingle | Nelson J.R. Fagundes Alice Tagliani-Ribeiro Rohina Rubicz Larissa Tarskaia Michael H. Crawford Francisco M. Salzano Sandro L. Bonatto How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data Genetics and Molecular Biology Isolation with Migration model coalescent analysis native Siberians |
| title | How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data |
| title_full | How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data |
| title_fullStr | How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data |
| title_full_unstemmed | How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data |
| title_short | How strong was the bottleneck associated to the peopling of the Americas? New insights from multilocus sequence data |
| title_sort | how strong was the bottleneck associated to the peopling of the americas new insights from multilocus sequence data |
| topic | Isolation with Migration model coalescent analysis native Siberians |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000200206&lng=en&tlng=en |
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